Phase 2 Lymphoma Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People diagnosed with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back or stopped responding to treatment
- People aged 18 years or older
- People whose bone marrow or blood shows at least 5% cancer cells, or where sensitive laboratory tests detect remaining cancer above a certain level, or where cancer that can be measured on a CT scan is present outside the bone marrow
- People who are in reasonably good general health, able to carry out light daily activities (confirm with trial site for exact fitness level required)
- People whose kidneys, liver, and other organs are functioning well enough to meet the trial's specific laboratory thresholds (confirm with trial site)
- People who are at least 2 weeks past any major surgery or radiation therapy, and who have waited the required time after any other experimental treatments, and have recovered from side effects of those prior treatments
- People who are willing and able to attend scheduled visits, follow the treatment plan, and complete required tests and procedures
- People who are willing to sign a consent form before any trial-related procedures begin
- Women who could become pregnant, and men with female partners who could become pregnant, who agree to use effective contraception during treatment and for a specified period afterward
Who may not be able to join:
- People whose leukemia has spread to the central nervous system (brain and spinal cord) and is currently active
- People with an active or ongoing hepatitis B or hepatitis C infection, or people known to be HIV-positive with a detectable viral load (people with HIV but an undetectable viral load may still be considered)
- People who have had major surgery less than 2 weeks before joining the trial
- People with an unstable or poorly controlled serious medical condition, such as heart or lung problems
- People who currently have another active cancer, other than certain limited types such as some skin cancers or early-stage cervical or prostate cancer that has already been fully treated — though people who have had a previous cancer and have been cancer-free for 2 or more years and are not currently receiving treatment for it may still be considered
- People with uncontrolled heart disease
- People who are pregnant or breastfeeding, or those not willing or able to use effective contraception as required during and after treatment
- People currently taking part in another experimental treatment study at the same time as this trial's active treatment phase
- People with other serious medical, psychiatric, or laboratory conditions that the treating doctor considers would make participation unsafe or affect the reliability of the trial results
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 773-834-8982
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Recommended Phase II Dose To demonstrate safety and to identify the recommended phase II dose for combination of LP-118, ponatinib, vincristine and dexamethasone
Can't join this trial?
Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.