Peripheral Arterial Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For the LEAD (leg artery disease) group:

• People who have been diagnosed with lower limb artery disease (a condition where reduced blood flow affects the legs)
• People experiencing symptoms ranging from no pain at rest through to severe limb pain or wounds, as classified by the Fontaine scale stages I through IV

For the comparison (control) group:

• People aged between 35 and 85 years
• People who have at least one of the following: high blood pressure, diabetes, heart artery disease, or who currently smoke

Who may not be able to join:

• People younger than 35 or older than 85 years
• People with a body mass index (BMI) of 40 or higher (confirm with trial site for exact calculation)
• People who have a history of heart failure
• People with any autoimmune or rheumatic disease (conditions where the immune system attacks the body, such as rheumatoid arthritis or lupus)
• People with a history of certain structural heart diseases, including inflammatory, infiltrative, or non-ischaemic heart muscle diseases
• People who have had a heart attack or acute heart event within the last 3 months
• People with moderate to severe heart valve disease
• People who have previously had surgery or a procedure to treat a heart valve
• People who have a device implanted in their heart, such as a pacemaker or defibrillator
• People who have had a mini-stroke (TIA) or stroke within the last 3 months
• People with severe chronic lung disease (classified as GOLD stage C or D)
• People with moderate to severe asthma (as defined by GINA 2022 guidelines)
• People with untreated high blood pressure measuring 180/110 mmHg or higher at the time of recruitment
• People with severely reduced kidney function (eGFR below 30 ml/min/1.73 m²)
• People who have received radiation to the chest area, or who have a history of cancer treatment including chemotherapy or biological therapies
• People with a chronic blood disorder (other than anaemia)
• People with severe liver disease
• People who have had a cancer diagnosis and have been in remission for less than 5 years
• People with an active or ongoing infectious disease
• People with anaemia where the haemoglobin level is below 80 g/L

Important: Always verify eligibility with the trial site directly before applying.