Crohn's Disease and Colitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
All participants:
- Children and young people under 18 years old who are seen or admitted in the Gastroenterology department at Necker-Enfants Malades Hospital.
- Parents (and the patient, where appropriate) have been informed about the study and have given their consent.
Group 1 – Children with active ulcerative colitis (UC):
- Children diagnosed with UC (a type of bowel inflammation) for more than 3 months, affecting more than just the very last part of the bowel (less than 5 cm).
- The UC is currently in a flare, meaning symptoms are moderate, based on a standard scoring tool used by doctors (PUCAI score between 35 and 65).
Group 2 – Children with UC in remission:
- Children diagnosed with UC for more than 3 months, affecting more than just the very last part of the bowel (less than 5 cm).
- The UC is currently settled, with very few or no symptoms, based on the same standard scoring tool (PUCAI score below 10).
Group 3 – Healthy comparison group:
- Children already scheduled for a routine internal camera examination (endoscopy) to investigate abdominal pain, acid reflux, or bowel polyps.
Who may not be able to join:
All participants:
- Children who have taken antibiotic or antifungal medications in the four weeks before joining the study.
- Children who are carriers of a specific gut bacteria called C. difficile.
- Young girls who are pregnant or breastfeeding.
- Cases where parents or the patient decline to take part.
Groups 1 and 2 – UC patients:
- Children whose bowel condition has not been clearly classified, or who have Crohn's disease instead of UC.
- Children whose UC affects only the very last section of the bowel (less than 5 cm).
- Children who have previously had their colon surgically removed.
- Children who have a bile duct condition (sclerosing cholangitis) alongside their UC, or who have liver disease.
Group 3 – Healthy comparison group:
- Children with a long-term (chronic) liver condition.
- Children with a long-term digestive condition such as coeliac disease or inflammatory bowel disease (confirm with trial site for full list).
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Bénédicte Pigneur, MD, Assistance Publique - Hôpitaux de Paris
Phone: 1 44 49 25 16
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Composition of bile acids
Can't join this trial?
Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.