Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman between 18 and 75 years old
• You are generally healthy and able to carry out daily activities with little or no limitation (confirm with trial site regarding the specific fitness scale used)
• You have been diagnosed with invasive breast cancer where the main tumor is larger than 2 cm and the cancer is considered locally advanced (has not spread to distant parts of the body)
• Your breast cancer has tested positive for a protein called HER2
• Your cancer has been tested for hormone receptors (ER and PR), and the results are known
• Your blood test results show that your blood cells, liver, kidneys, and other major organs are working well enough to meet specific levels set by the trial (confirm with trial site for exact values)
• Your heart is pumping well, with a heart function score of at least 60% on an ultrasound, and your heart's electrical activity is within a safe range on a heart tracing test
• If you could become pregnant, you agree to use effective birth control during the trial and for at least 7 months after your last dose of the study treatment, or to abstain from sex during that time
• You are willing to take part voluntarily, sign a consent form, and attend follow-up appointments

Who may not be able to join:

• Your breast cancer has spread to other parts of the body (stage IV or metastatic)
• You have previously received cancer treatment or radiotherapy for any cancer, unless it was a fully cured early-stage skin cancer or cervical pre-cancer
• You are currently taking part in another clinical trial that involves cancer treatment, including hormone therapy, bone-strengthening drugs, or immunotherapy
• You had a major surgery unrelated to breast cancer within the 4 weeks before joining, or you have not fully recovered from such a surgery
• You have a serious heart condition, such as heart failure, uncontrolled irregular heartbeat, chest pain requiring medication, significant heart valve problems, a previous full-thickness heart attack shown on a heart tracing, or poorly controlled high blood pressure
• You have difficulty swallowing, a blocked bowel, or any other condition that would stop you from taking or absorbing the trial medication
• You have a known allergy to any of the drugs used in this trial, a weakened immune system (including HIV), another immune deficiency condition, or a history of organ transplant
• You are currently pregnant or breastfeeding, have tested positive on a pregnancy test at the start of the trial, or are unwilling to use effective contraception during the trial and for 7 months after your last dose
• You have other serious health conditions that could interfere with the treatment, or the trial doctor feels the trial is not appropriate for you for any other reason

Important: Always verify eligibility with the trial site directly before applying.