Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are suspected of having an acute ischemic stroke (a stroke caused by a blockage in a blood vessel in the brain)
• People whose stroke is likely caused by a blockage in a large or medium-sized blood vessel in the brain
• People aged 18 years or older
• People who were functioning mostly independently before their stroke (scored 0–2 on a standard disability scale called the modified Rankin Scale)
• People who arrive at the enrolling hospital within 24 hours of when they were last known to be well or when their stroke symptoms started
• People for whom a procedure to remove the clot can be started within 2 hours of the qualifying brain scan
• People who fall into one of these two groups:
  • Those with a blocked main brain artery (ICA or M1 MCA) but only mild stroke symptoms (a score of 0–5 on a standard stroke severity scale called the NIHSS, with at least some noticeable symptoms related to the blockage)
  • Those with a blockage in a smaller or more distant brain artery (such as a non-dominant or co-dominant M2 or M3 branch), with a stroke severity score of 8 or higher on the NIHSS, and — if symptoms started more than 6 hours ago — with only a small area of permanently damaged brain tissue as shown on brain imaging

Who may not be able to join:

• People who are currently prisoners or incarcerated
• People for whom the clot-removal procedure (endovascular thrombectomy) has been ruled out for a confirmed medical reason
• People whose stroke is suspected to be caused by an infected clot or bacterial heart infection (endocarditis)
• People who had a seizure at the time their stroke started or at any point before enrolling in the trial
• People with a known severe allergic reaction to contrast dye that would prevent the clot-removal procedure
• People whose blocked blood vessel is thought to have been blocked for a long time (chronic occlusion), based on their history or brain scans
• People whose blockage appears to be caused by a tear inside a brain artery (intracranial dissection), based on their history or brain scans
• People with inflammation of the brain's blood vessels (cerebral vasculitis), based on their history or brain scans
• People who are known to be pregnant
• People with a pre-existing medical, neurological, or psychiatric condition that would make it difficult to assess stroke-related outcomes
• People with a serious, advanced, or terminal illness, or whose life expectancy is estimated to be less than 6 months
• People known or strongly suspected to have a condition called intracranial atherosclerotic disease (a narrowing of brain arteries due to plaque build-up)
• People with a platelet count (a blood clotting measure) known to be below 100,000/uL
• People whose brain scan shows a large area of already-damaged brain tissue (CT ASPECT score below 6, or MRI ASPECT score below 7)
• People whose blood vessel shape or structure makes it physically impossible to reach the blockage with the procedure
• People with blockages in more than one separate brain artery area at the same time
• People with a blockage in two connected sections of an artery (called a tandem occlusion)
• People whose brain scan shows significant swelling causing the brain to shift more than 5mm to one side
• People with evidence of a brain tumour on their scan, except for a small, symptom-free meningioma (3cm or smaller)
• People with evidence of bleeding inside the skull on their brain scan

Important: Always verify eligibility with the trial site directly before applying.