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Asthma Trial, Recruiting
NCT06299592
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 75 years old
- You are able to understand the study and are willing to sign a consent form agreeing to take part
- You are able to cooperate with the study procedures and requirements
- You have a specific genetic profile related to how a certain protein (called TSPO) binds in your body (a mixed version of this genetic profile may also be considered at the lead researcher's discretion)
- You are able to tolerate sitting through a session that simulates an MRI brain scan
- For people with severe asthma: you have had a doctor's diagnosis of asthma for at least six months before the screening visit, and your asthma meets a specific medical definition of "severe" or you are currently on a high-level asthma treatment plan (confirm with trial site)
- If you do not have asthma, you are generally in good health with no conditions that could affect the study results
Who may not be able to join:
- You currently smoke more than half a pack of cigarettes per week, have smoked at any point in the two weeks before the study, or have a significant smoking history in the past 10 years
- You are currently receiving allergy shots (immunotherapy), unless your dose has been stable for a period of time
- You are taking certain psychiatric or mood-related medications that could affect the brain pathways being studied (the lead researcher will decide)
- You are unable to temporarily stop certain medications as required by the study's medication schedule
- You have a fear of needles or of enclosed spaces (such as an MRI machine)
- You have had a serious heart or brain event in the last 6 months, such as a stroke, heart attack, or related condition; other major health conditions such as autoimmune disease, uncontrolled high blood pressure, lung diseases other than asthma, or irregular heart rhythms may also affect eligibility (confirm with trial site)
- You are taking certain biologic medications that could interfere with the processes being studied (the lead researcher will decide)
- You have an ongoing long-term infectious disease
- You regularly take a specific type of heart/blood pressure medication called non-selective beta-blockers around the time of study visits
- You have taken an experimental drug within the last 30 days, or possibly longer depending on the drug (the lead researcher will review this individually)
- You have anything that makes it unsafe for you to have an MRI scan, as identified by the MRI screening form
- You have a diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder
- You have a history of serious head injury or a seizure disorder (though exceptions may be considered by the lead researcher)
- You are pregnant, breastfeeding, or planning to become pregnant during the study
- You have any other medical condition that the lead researcher believes could affect your safety or the quality of the study data
- The lead researcher does not believe you would be able to follow instructions or complete the study procedures
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.
Contact this trial
Principal Investigator: Melissa Rosenkranz, PhD, University of Wisconsin, Madison
Phone: 608-263-0524
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
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Trial details
Status
Recruiting
Phase
Not Applicable
Sponsor
Registry
ClinicalTrials.gov
Start date
6 March 2024
Est. completion
1 August 2028
Where this trial is recruiting
🇺🇸 United States
Primary endpoints
Binding of [18F]-FEPPA
Can't join this trial?
Data last synced from ClinicalTrials.gov: 13 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.