Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a man, or a woman who is not pregnant or breastfeeding, and you are 18 years old or older
• Your cancer cannot be cured with currently available treatments
• You have already tried the standard treatments available for your condition, and those options are no longer expected to help you live longer
• Your cancer can be measured on a scan (using standard imaging guidelines), and at least one area of cancer has not been previously treated with radiation
• You are fairly active and able to carry out daily activities with little or no limitation (confirm with trial site what this means for your specific situation)
• Your doctor estimates you are expected to live for more than 12 weeks from causes related to your disease
• You are willing to allow researchers to use stored tissue samples to test for certain biological markers
• You are willing to have a detailed lung CT scan (without contrast dye) and breathing/lung function tests at the start of the trial
• Your organs (such as kidneys, liver, and blood cells) are working well enough as determined by tests
• Any side effects from previous treatments have mostly gone away, except for certain lasting effects like hair loss, skin colour changes, mild nerve problems from prior chemotherapy, or stable hormone-related issues being managed with medication
• If you are able to become pregnant and are sexually active with a partner who has not been sterilised, you must agree to use at least one reliable method of contraception during the study and for a set period after finishing treatment
• You are able to understand the study, give written consent, and follow all study-related requirements
• You have a history of following medical instructions and are willing to cooperate with the study team
• You are willing to sign and date the study consent form

Who may not be able to join:

• You are pregnant, breastfeeding, or have a positive pregnancy test during the screening period
• You have had a serious allergic reaction to the study drug or similar drugs in the same class
• Your cancer has already stopped responding to a specific type of chemotherapy drug (called a topoisomerase-I inhibitor), meaning it got worse during treatment or within 6 months of your last dose
• You are currently taking part in another clinical trial, or have done so within the past 28 days, or within a certain window based on the last experimental treatment you received
• You have cancer that has spread to your spinal cord or is currently active in your brain or nervous system
• You have had radiation therapy less than 2 weeks before joining the trial
• You have had major surgery within 21 days before signing the consent form, unless you have fully recovered
• You have a history of lung inflammation (not caused by infection) that needed steroid treatment, or you currently have lung inflammation
• Your blood oxygen level while resting and breathing normal air is below 93%
• Your lung function tests show your lungs are working below certain levels (confirm with trial site)
• You have an abnormal heart rhythm reading on an ECG that is above a certain level (confirm with trial site)
• You have a history of a kidney condition called nephrotic syndrome
• You have an active eye (cornea) condition, or have had one within the past 12 months
• You have an active, uncontrolled serious condition affecting your kidneys, liver, heart, digestive system, nervous system, or blood that your doctor believes could put you at risk during treatment
• You have had another cancer in the past 2 years that is still being treated or has not been fully cleared, with some exceptions for certain low-risk cancers
• You have serious uncontrolled heart conditions such as unstable chest pain, a heart attack in the last 6 months, a heart valve problem needing treatment, heart muscle inflammation, or severe heart failure
• You are currently receiving chemotherapy, radiation therapy (except for targeted local treatment of specific lesions), immunotherapy, or steroid treatment
• You have received a live vaccine within 30 days before starting the trial
• You have certain active or ongoing infections, including uncontrolled hepatitis B or C, poorly managed HIV, or any other active bacterial, viral, fungal, or similar infection — some infections may be acceptable if well controlled (confirm with trial site)
• You have a history of a serious brain infection called progressive multifocal leukoencephalopathy
• You have a history of severe or frequently recurring infections, as judged by your doctor

Important: Always verify eligibility with the trial site directly before applying.