Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have been diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL) that has not been treated before, or has had only minimal prior treatment (no more than one or two courses of chemotherapy), and where the leukaemia is still detectable at low levels in the blood or bone marrow.
• People aged 12 or older who have Ph+ ALL that has come back or has not responded to previous treatment, or who have a related condition called lymphoid blast phase CML that has been previously treated.
• People who are well enough to carry out basic daily activities, as measured by standard medical scales (confirm with trial site for exact score requirements).
• People who weigh at least 40 kg.
• People whose liver is working well enough, based on blood test results (unless any abnormal results are thought to be caused by the leukaemia itself).
• People whose kidneys are working well enough, based on a standard kidney function measurement.
• People whose pancreas is working well enough, based on blood test results.
• People whose heart is functioning adequately, as assessed by a doctor.
• Women who could become pregnant must have a negative pregnancy test before joining the trial.
• People who are willing to use reliable contraception before, during, and for four months after taking part in the trial.
• People who are willing and able to give written informed consent to participate.

Who may not be able to join:

• People who have a serious active infection that is not being controlled by antibiotics taken by mouth or through a drip.
• People who have another active cancer (other than certain common skin cancers) that a doctor believes is likely to reduce life expectancy to less than one year.
• People who have severe heart failure (Grade III–V as defined by standard heart failure criteria).
• People whose heart's electrical activity shows a prolonged interval on an ECG recording (above a certain measurement), unless this is corrected by treatment and approved by a heart specialist.
• People who have a significant history of certain brain or nervous system conditions, such as epilepsy, stroke, dementia, Parkinson's disease, or psychosis (note: leukaemia that has spread to the brain does not automatically exclude someone — confirm with trial site).
• People who have received an experimental anti-leukaemia treatment or chemotherapy within the seven days before joining the trial, unless they have fully recovered from side effects, or unless their disease is rapidly worsening in a life-threatening way.
• Women who are pregnant or breastfeeding.
• Men enrolled in the trial are expected to understand the risks to any partner who could become pregnant and to use effective contraception.

Important: Always verify eligibility with the trial site directly before applying.