Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to give written consent to participate
• Adults between 18 and 65 years of age
• Women who are not pregnant (confirmed by a pregnancy test), not breastfeeding, and either unable to become pregnant naturally or using a highly effective form of contraception throughout the study (such as implants, injections, the pill, hormonal IUDs, or double-barrier methods)
• People who have had mild asthma for at least 12 months before screening, managed only with a short-acting reliever inhaler (such as a "blue puffer")
• People whose body weight is in a healthy range for their height (BMI between 18 and 32)
• People whose lung function tests show results within normal limits at the screening visit
• People who have had a positive skin prick allergy test (a reaction of 3mm or more) to a specific airborne allergen such as grass, tree, weed pollen, or house dust mite, within the past 12 months (confirm with trial site)
• People who have shown both an early and late asthmatic reaction during a previous inhaled allergen challenge test (confirm with trial site)
• People who are able to produce an adequate sputum (mucus) sample when tested (confirm with trial site)
• Non-smokers who have smoked less than the equivalent of one pack of cigarettes per year in total, and have not smoked for at least the past year

Who may not be able to join:

• People with any significant abnormal results on physical examination, blood tests, urine tests, heart tracing (ECG), or lung function at screening, where the trial doctor believes this could affect safety or results
• People with a current or past serious illness that the investigator believes may affect the study, including heart disease, cancer, liver disease, kidney disease, blood disorders, neurological conditions, most metabolic or hormonal conditions, or lung diseases such as emphysema, chronic bronchitis, tuberculosis, or cystic fibrosis (note: stable, symptom-free underactive thyroid and a condition called Gilbert's syndrome are generally allowed)
• People who regularly take any prescription or over-the-counter medicines, with exceptions for paracetamol, contraceptives, hormone replacement therapy, and vitamin or dietary supplements
• People who have had allergen immunotherapy (desensitisation treatment) within the past three years
• People who have taken steroid medicines (by mouth, injection, or inhaler) in the four weeks before the screening visit
• People who have had a respiratory tract infection (such as a chest or throat infection) in the four weeks before the screening visit
• People who have had an asthma flare-up in the three months before the screening visit
• People who have ever had a life-threatening asthma attack that required a breathing tube or caused a respiratory emergency
• People who may be allergic to any of the medicines used during the bronchoscopy procedure, such as bronchodilators, sedatives, or local anaesthetics
• People who have any condition that would make a bronchoscopy (a procedure to look inside the airways) or allergen challenge test unsafe or not possible
• People who are unable to have an MRI scan, for example due to claustrophobia, a pacemaker, or a known allergy to MRI contrast dye
• People who have taken part in a clinical trial involving an investigational medicine within the past 30 days, or within 5 half-lives of that medicine (whichever period is longer)
• People currently in the observation period of another competing study within 30 days before screening
• People who have had a segmental allergen challenge procedure (a specific airway test) within three months before the bronchoscopy
• People who have donated more than 400ml of blood in the 60 days before screening
• People with a history of regular drug or alcohol misuse
• People who the investigator believes are unlikely to follow the study procedures
• People who may not be able to understand the requirements and instructions of the study

Important: Always verify eligibility with the trial site directly before applying.