Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 1 to 18 years old
• People who have been diagnosed with B-cell acute lymphoblastic leukaemia (a type of blood cancer) that has come back or has not responded to treatment, and whose cancer cells test positive for certain markers called CD19 and CD22 (at more than 95% on flow cytometry testing)
• People whose cancer has not responded to, or who could not tolerate, all standard treatments — including immunotherapies such as Blinatumomab, tyrosine kinase inhibitors, CAR T-cell therapy, and others — and for whom no curative options such as stem cell transplant or chemotherapy are currently available
• People whose blood shows a very high level of cancer cells (60% or more), or who have severely low blood cell counts that make it impossible to collect their own immune cells for treatment
• People whose doctors estimate they are likely to survive at least 60 days
• People with a general health status rated 0 to 2 on the ECOG scale, meaning they are able to carry out everyday activities with at most some limitations (confirm with trial site)
• People who have a matching donor available — either a full or half-matched (haploidentical) family or unrelated donor — who tests negative for donor-specific antibodies (DSA), for the purpose of donating blood cells and stem cells
• People (or their legal guardians) who are willing and able to sign a consent form during the screening period. Children aged 8–18 who have sufficient understanding must sign themselves, along with their guardian. Children aged 1–7 may be enrolled based on their guardian's consent alone.

Who may not be able to join:

• People who have previously had a stem cell transplant (either from bone marrow or from blood)
• People who have increased pressure in the brain or reduced consciousness
• People with symptomatic heart failure or a serious heart rhythm problem
• People with severe breathing difficulties or respiratory failure
• People who have another type of cancer in addition to leukaemia
• People with a condition called diffuse intravascular coagulation (a serious blood clotting disorder)
• People whose kidney function tests (creatinine and/or urea nitrogen) show levels at 1.5 times or more above the normal range
• People who have sepsis (a serious whole-body infection) or another infection that cannot be controlled
• People with diabetes that cannot be controlled with treatment
• People with a severe mental health disorder
• People who have significant abnormalities on a brain MRI scan, other than those caused by leukaemia that has spread to the brain
• People who have previously had an organ transplant
• People who are female and of childbearing potential and have a positive blood pregnancy test
• People who test positive for Hepatitis B, Hepatitis C, HIV/AIDS, or syphilis
• People for whom no suitable donor is available to provide blood immune cells and stem cells

Important: Always verify eligibility with the trial site directly before applying.