Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older at the time of giving consent to join the trial
• People who have been diagnosed with a type of B-cell non-Hodgkin's lymphoma (a blood cancer) that has been confirmed by a tissue test
• People whose organs (such as kidneys, liver, and heart) are functioning well enough to meet the trial's requirements
• People whose lymphoma has come back or stopped responding to treatment, in one of the following ways: after at least 2 rounds of treatment (or at least 1 round for certain specific lymphoma types including Burkitt lymphoma, Precursor B-cell lymphoblastic lymphoma, or Mantle cell lymphoma); or the cancer came back or got worse within 12 months of a stem cell transplant using the patient's own cells; or for people who cannot have a stem cell transplant, the cancer did not respond well enough to earlier lines of treatment (confirm with trial site for full details)
• People who have previously received a specific combination of treatments that included both an anti-CD20 antibody therapy (a type of targeted drug) and a chemotherapy regimen containing a drug called an anthracycline
• People whose lymphoma shows up as active on a PET scan (a type of imaging test) based on specific 2014 guidelines
• People who are well enough to carry out basic daily activities, based on a standard health performance scale (scored 0, 1, or 2 out of 5)
• People whose side effects from previous treatments have mostly settled, with symptoms at a mild level (Grade 1 or lower)

Who may not be able to join:

• People who have previously received a cell-based therapy that targeted a protein called CD19
• People with a history of a condition called Richter's transformation, which is a change from a type of blood cancer called chronic lymphocytic leukaemia
• People who have had another separate cancer that has not been in remission for at least 2 years
• People with a history of, or currently living with, a significant condition affecting the brain or spinal cord
• People whose lymphoma has spread to the brain or spinal cord and is getting worse, or where a mass in the brain may soon cause symptoms
• People who have lymphoma actively involving the heart that is not responding to treatment
• People who have had a heart attack, a procedure to open blocked heart arteries, a heart stent placed, unstable chest pain, or another serious heart condition within the past 6 months
• People with an active, uncontrolled infection caused by bacteria, fungi, or a virus (note: people with HIV, hepatitis B, or hepatitis C may still be considered eligible if their infection is being treated and the virus is under control — confirm with trial site)
• People with a history of an autoimmune disease (where the immune system attacks the body) that caused organ damage or required ongoing immune-suppressing medication within the last 2 years
• People who have had a serious allergic reaction to any of the medicines used in this trial, including the preparatory chemotherapy drugs
• People with a blood clot in a vein or a clot that has travelled to the lungs, if it is not being managed on a stable blood-thinning treatment
• People who have had a stem cell transplant using their own cells within the 3 months before giving consent to join the trial
• People who have had a stem cell transplant using someone else's cells, if they are experiencing a complication called graft-versus-host disease that still requires treatment with steroids or other specific medications within the past 12 weeks
• People who have received a live vaccine within 3 months before the planned start of the preparatory treatment for the trial

Important: Always verify eligibility with the trial site directly before applying.