Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older who have been diagnosed with certain blood cancers — including acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), mixed-type acute leukaemia, myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia (CMML), or CML in blast phase — and whose disease is in remission or at a specific stage as defined by the trial (confirm with trial site for exact disease stage requirements)
• People whose doctor considers them well enough to undergo a stem cell transplant from a donor (allogeneic HCT)
• People who have completed at least two rounds of intensive chemotherapy before joining the trial
• People who have received broad-spectrum antibiotics within the 3 months before joining the trial
• People with a Karnofsky performance score of 60 or above, which means they are able to care for most of their own needs with some assistance (confirm with trial site)
• People of reproductive potential who are willing to use highly effective contraception from the start of treatment until 6 months after treatment ends
• People who are willing and able to attend scheduled study visits and complete required tests
• People who have given written informed consent to participate

Who may not be able to join:

• People who have a medical reason that makes a donor stem cell transplant unsafe for them
• People who are pregnant or breastfeeding, or women of childbearing potential who have a positive pregnancy test before starting treatment
• People of reproductive potential who are not willing to use highly effective contraception during the required period
• People with significant kidney or liver problems, as assessed by their doctor
• People with an active infection, or who are HIV-positive, or who have active chronic hepatitis B or hepatitis C
• People with another current or previous cancer, with some exceptions — certain skin cancers, early-stage cervical or prostate cancer findings, and cancers treated with curative intent 5 or more years ago may still be eligible (confirm with trial site)
• People who have difficulty swallowing capsules
• People who have received the investigational treatment (IMT) within the 3 months before joining the trial
• People who are taking probiotic supplements after joining the trial
• People with certain gut or digestive conditions, including coeliac disease, inflammatory bowel disease, irritable bowel syndrome, cystic fibrosis, chronic diarrhoea, delayed stomach emptying, or a history of bowel perforation or fistula
• People with an autoimmune disease that requires or may require ongoing treatment with steroids or immune-suppressing medications
• People with a significant bleeding disorder (note: blood cancers that meet the inclusion criteria above are not automatically excluded on this basis — confirm with trial site)
• People with a severe food allergy that could cause anaphylaxis
• People who require medications to maintain blood pressure (vasopressors)
• People with heart valve disease or known structural heart defects
• People with a known severe allergy to any of the capsule ingredients used in the trial

Important: Always verify eligibility with the trial site directly before applying.