Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman aged 51 or older
• You have breast cancer that has come back in the same breast, or a new breast cancer in the same breast you were previously treated
• Your cancer has been confirmed by biopsy as either an invasive breast cancer (with or without a non-invasive component) or a non-invasive type called DCIS that shows up as calcium deposits on imaging
• Your cancer has been confirmed by biopsy to be estrogen receptor (ER) positive (meaning it is fuelled by the hormone oestrogen)
• Your cancer has been confirmed to be HER2 negative (a specific protein is not present in high amounts)
• If your cancer is invasive, the tumour is no larger than 3 cm; if it is DCIS only, the affected area is no larger than 2.5 cm
• Your tumour is classed as grade 1 or grade 2 (low to moderate growth rate), based on biopsy results
• There is no sign that the cancer has spread to your lymph nodes or other parts of the body
• The cancer appears in just one area on mammogram and MRI scans (small closely neighbouring spots may still be acceptable — confirm with trial site)
• It has been more than 12 months since you completed treatment for your original breast cancer
• You previously had radiotherapy to the same breast
• Surgeons have confirmed it is possible to remove the cancer again while keeping the breast (repeat breast-conserving surgery)
• You are generally well enough to take part, based on a standard health assessment scale (WHO performance score of 2 or below)
• You are able to give written consent to take part and are legally able to make your own decisions

Who may not be able to join:

• You experienced severe side effects (grade 3 or higher) from radiotherapy to the breast during your previous treatment
• You previously had a focused "boost" of radiotherapy aimed directly at the tumour area — unless the current tumour is in a different area of the breast that did not receive that boost
• Your cancer has spread to other parts of the body, or you also have a new cancer in the opposite breast
• Your biopsy has shown a specific type of breast cancer called invasive lobular carcinoma (ILC) or pleomorphic lobular carcinoma in situ (LCIS)
• Your cancer is oestrogen receptor (ER) negative
• Your biopsy shows that cancer cells have spread into nearby blood or lymph vessels (lymphovascular invasion)
• You have already received, or are planned to receive, chemotherapy or other systemic drug treatment for this current tumour before surgery (a short course of hormone therapy of up to 2 months before surgery is an exception)
• You are planned to have a type of surgery that involves moving large amounts of tissue from another area to reshape the breast
• You are already taking part in another clinical trial that involves treatment to the breast or surrounding area
• Doctors believe it will not be possible to give radiotherapy at safe levels that protect your lungs and heart (confirm with trial site)
• You have a confirmed BRCA gene mutation

Important: Always verify eligibility with the trial site directly before applying.