Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman aged 18 or older
• You have been diagnosed with advanced ovarian cancer, primary peritoneal cancer, or fallopian tube cancer (confirmed by a lab test), excluding a type called carcinosarcoma, and have received at least one round of platinum-based chemotherapy
• You have already received standard treatments that were likely to help you, such as PARP inhibitors (if you have a BRCA gene mutation or a related gene repair problem) or bevacizumab, if those were appropriate for you
• Your cancer has come back or gotten worse after your most recent treatment
• You have at least 2 areas of cancer that can be measured or detected, and enough tumor tissue can be safely removed for the trial's manufacturing process (about 1 gram)
• You are generally well enough to carry out daily activities, based on a standard health scale rated 0–2 (confirm with trial site)
• Any side effects from previous treatments have mostly resolved, except for hair loss, nerve-related issues, or hearing problems
• Your blood, liver, and kidney test results are within acceptable ranges, tested within 28 days before the trial starts
• If you could become pregnant, you have a negative pregnancy test and agree to use reliable contraception throughout the trial
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You have a history of HIV, Hepatitis C (HCV), Hepatitis B (HBV), or HTLV-1/2 infections
• You have been diagnosed with any condition that weakens your immune system, whether inherited or acquired
• You have an active or past history of an autoimmune disease — though some conditions may be allowed if they do not require immune-suppressing treatment, such as stable Type 1 diabetes, vitiligo, thyroid conditions, or autoimmune hair loss (confirm with trial site)
• You have taken steroid tablets or other immune-suppressing medicines within 14 days before the trial vaccine is due to start (inhaled or topical steroids are generally allowed)
• You currently have an active infection requiring treatment that has not fully cleared at least 7 days before the trial starts
• You have received a live or weakened (attenuated) vaccine for an infectious disease within 28 days before the trial vaccine is due to start (inactive vaccines, including most COVID-19 vaccines, are generally allowed)
• You have taken part in another clinical trial and received an experimental treatment within 4 weeks before the trial starts
• You have received an approved cancer treatment within 3 weeks before the trial starts
• You have had a previous different cancer, unless it was fully treated and has not returned within the last 5 years (some treated skin cancers may be exceptions — confirm with trial site)
• You have any other health condition, circumstance, or history that the trial doctor believes could affect the trial results or make participation not in your best interest
• You are unable to follow the trial's procedures or attend follow-up appointments

Important: Always verify eligibility with the trial site directly before applying.