Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with high-risk prostate cancer (a specific type called adenocarcinoma), confirmed by a tissue sample test
• People whose cancer has been staged at certain levels (T1c through T4, with lymph nodes ranging from not affected to affected, and either no spread to distant parts of the body or limited spread), based on standard cancer staging guidelines
• People whose cancer has at least one high-risk feature, such as a Gleason score of 8–10 (a measure of how aggressive the cancer looks under a microscope), cancer that has grown beyond the prostate (T3–T4), or a PSA level of 20 or higher (a blood marker for prostate cancer)
• People who are reasonably well and able to carry out daily activities, as measured by a standard health performance scale (scores 0–2)
• People who are willing and able to sign a consent form approved by an ethics review board
• People who have completed all required tests before joining the trial
• People who are at least 18 years old
• People whose cancer has spread to no more than 5 distant or regional areas in the body (this applies to a specific group within the trial — confirm with trial site)

Who may not be able to join:

• People who have previously had radiation therapy to the pelvis
• People who have taken hormone-suppressing treatment for prostate cancer for more than 6 months
• People who currently have active rectal diverticulitis, Crohn's disease affecting the rectum, or active ulcerative colitis (non-active cases or Crohn's disease not involving the rectum may still be eligible — confirm with trial site)
• People who have previously received chemotherapy for prostate cancer
• People who have a history of a narrowing of the upper part of the urethra (the tube that carries urine) that required a procedure to widen it
• People who are currently taking blood-thinning medications such as warfarin, heparin, low-molecular weight heparin, clopidogrel, or similar drugs on an ongoing basis, unless those medications can be temporarily stopped when needed during the trial
• People with a serious medical, addiction-related, or psychiatric condition that, in the opinion of the trial doctor, would prevent them from giving proper consent, completing treatment, or attending follow-up appointments
• People who have had another type of cancer in the past 5 years and have less than a 50% chance of surviving 5 years (certain skin cancers may be an exception — confirm with trial site)
• People who have had a heart attack or serious heart failure within the past 6 months

Important: Always verify eligibility with the trial site directly before applying.