Phase 2 Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 65 years old
• You can read, speak, and understand English well enough to give consent, complete questionnaires, and take part in treatment
• You have a primary diagnosis of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), or schizophrenia, confirmed by a structured clinical interview
• If you have MDD, your depression scores at least 20 on a standard depression questionnaire (the Beck Depression Inventory)
• If you have GAD, your anxiety scores at least 16 on a standard anxiety questionnaire (the Beck Anxiety Inventory)
• If you have OCD, your symptoms score at least 16 on a standard OCD scale (the Yale-Brown Obsessive-Compulsive Scale)
• If you have schizophrenia, your symptoms score at least 58 on a standard schizophrenia scale (the Positive and Negative Symptom Scale)
• Your psychiatric medications have stayed the same for at least 4 weeks before the trial starts, or you are not taking any psychiatric medications
• You have a primary mental health care provider (such as a psychiatrist, therapist, psychologist, or similar) who will continue to look after you before, during, and after the trial

Who may not be able to join:

• You are currently pregnant, based on a urine pregnancy test
• You have been diagnosed with a Cluster B personality disorder, such as antisocial, borderline, histrionic, or narcissistic personality disorder
• You have PTSD with active, significant symptoms as determined by a clinician
• You have a diagnosis of schizoaffective disorder, bipolar type
• You have used ketamine, esketamine, or had electroconvulsive therapy (ECT) in the past 4 weeks, or are currently using these treatments
• You have a metal implant in your body that would make it unsafe to receive TMS (brain stimulation therapy) or have an MRI scan
• You have any other safety concerns related to TMS or MRI, as identified by a clinician
• You are currently receiving or planning to receive other TMS treatments while taking part in this trial
• You have a history of brain surgery for a mental health condition
• You have moderate to severe autism spectrum disorder
• You have an intellectual disability
• You have severe problems with thinking, memory, or cognition
• You have a significant neurological condition, such as dementia, Parkinson's disease, Huntington's disease, a brain tumor, a seizure disorder, a blood clot around the brain (subdural hematoma), or multiple sclerosis
• You have an untreated or poorly managed hormone or gland disorder (such as a thyroid condition) (confirm with trial site)
• You have a history of an eating disorder
• You are taking part in another clinical trial involving an experimental drug or treatment during the study period
• You are currently experiencing mania or hypomania (an elevated or unusually high mood state)
• You currently have active thoughts of suicide, or you have made a suicide attempt in the past year
• You have any other reasons that would make TMS or MRI unsafe for you (such as metal implants)
• You currently have a moderate or severe substance use disorder, or are showing signs of withdrawal from a substance
• A clinician has determined that you have a significantly higher-than-normal risk of having a seizure
• If you have schizophrenia: a licensed psychiatrist or psychologist on the study team believes you may not be able to fully understand and consent to taking part in the trial
• If you have schizophrenia: you have been hospitalised due to psychosis in the past 6 months
• A urine drug test shows the presence of illegal substances
• You currently have tinnitus (a persistent ringing or buzzing in your ears)
• You have any other condition that the lead researcher believes could interfere with the study or put you at greater risk

Important: Always verify eligibility with the trial site directly before applying.