Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent and agreed to take part in the study voluntarily.
• People whose esophageal cancer has been confirmed as squamous cell carcinoma through a tissue or cell sample test.
• People whose cancer is located in the chest portion of the esophagus and has been staged at a specific level (T1N1-3M0 or T2-3N0-3M0, including spread only to lymph nodes near the collarbone) based on CT or PET-CT scans, according to standard cancer staging guidelines.
• People whose cancer is expected to be fully removed by surgery (called R0 resection).
• People who are over 75 years of age.
• People with a general health and activity level rated as 0 or 1 on a standard medical scale (meaning fully active or able to carry out light work).
• People who have not previously had any treatment for esophageal cancer, including radiation, chemotherapy, or surgery.
• People who have no medical reasons preventing them from having surgery.
• People whose blood, liver, kidney, and clotting function results meet specific levels set by the trial (confirm with trial site for exact values).
• Women of childbearing age whose pregnancy test, taken within 72 hours before the first treatment, is negative — and who agree to use contraception from the first dose until five months after the last dose. Male participants whose partners could become pregnant must also use contraception during this period.
• People who are willing to follow the trial schedule and attend all follow-up appointments.

Who may not be able to join:

• People who have previously had, or are currently receiving, any anti-cancer treatment such as radiation, chemotherapy, or immunotherapy.
• People who have taken high-dose steroid medications (equivalent to more than 10mg per day of prednisone) or other immune-suppressing drugs within the two weeks before starting the trial.
• People who have received a live vaccine within four weeks before starting the trial.
• People whose cancer is a type other than esophageal squamous cell carcinoma.
• People whose cancer cannot be surgically removed or has spread to distant parts of the body.
• People whose cancer staging does not meet the specific criteria required by the trial (confirm with trial site).
• People who have had another cancer within the past five years — although some exceptions may apply for certain early-stage or fully treated cancers such as cervical carcinoma in situ, certain skin cancers, or localised prostate cancer that received complete treatment (confirm with trial site).
• People with serious or uncontrolled heart conditions, such as significant heart failure, unstable chest pain (angina), a heart attack within the past year, or certain heart rhythm problems requiring treatment.
• People with a known active autoimmune disease (where the immune system attacks the body).
• People who are pregnant or breastfeeding.
• People with a known allergy or sensitivity to the medications used in the trial.
• People who are HIV positive, have active hepatitis B or C, or have active tuberculosis.
• People whom the trial investigators believe may not be suitable for other reasons.

Important: Always verify eligibility with the trial site directly before applying.