Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (a specific type called adenocarcinoma), confirmed by a biopsy.
• People who have already had radiation therapy to the prostate, or who are currently thinking about or scheduled for external beam radiation therapy (EBRT).
• People in one specific group (Part 2B) who have high-risk prostate cancer — meaning their cancer meets at least two of these three markers: the tumour has spread to surrounding tissue (stage T3 or T4), a Gleason score (a measure of cancer aggressiveness) of 8 to 10, or a PSA blood level of 40 ng/mL or higher — and who are planning to receive hormone-blocking therapy as part of their treatment.
• People in another specific group (Part 3) who have already had radiation to the prostate and are showing signs that the cancer may be returning, with a planned biopsy scheduled within 12 weeks after the study scan.
• People aged 18 or older at the time of joining the study.
• People who are generally well enough to carry out everyday activities with little or no limitation (confirmed by a standard health rating scale called ECOG, score of 0 or 1).
• People whose blood counts and kidney function meet the minimum levels required by the study, including white blood cell count, haemoglobin, platelets, and kidney filtering rate.
• People who are willing and able to follow the study procedures and sign a consent form.

Who may not be able to join:

• People whose cancer has spread to lymph nodes outside the pelvis, or to distant parts of the body, as seen on standard scans or a PSMA PET scan (small affected lymph nodes within the pelvis under 1 cm may still be considered — confirm with trial site).
• People who had a prostate biopsy within the 14 days before their study scan.
• People with poorly controlled high blood pressure — specifically, a reading above 160/100 mmHg at the time of joining (people who can bring their blood pressure under control with medication may be able to be re-assessed — confirm with trial site).
• People who are unable to have an MRI scan with an internal coil placed near the rectum, for example due to severe claustrophobia, a heart pacemaker, a certain type of surgical clip in the brain, or significant haemorrhoid or rectal problems.
• People with moderate to severe heart failure (rated as NYHA class 2 or higher on a standard heart function scale).
• People with a significant history of abnormal heart rhythm readings, a family history of a specific heart rhythm condition called long QT syndrome, or who have had a heart attack within 6 months of joining the study.

Important: Always verify eligibility with the trial site directly before applying.