Phase 3 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part and can sign a consent form agreeing to participate
• You are a woman aged 18 or older
• You have been diagnosed through testing with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer
• Your cancer has stopped responding to platinum-based chemotherapy (known as platinum-resistant disease)
• You are able to provide a tumour tissue sample, either a fresh one or one stored from a previous procedure
• You have at least one tumour that can be measured using standard imaging scans
• You are generally able to carry out daily activities with no or only minimal limitations (confirm with trial site)
• You are expected to live for at least 12 weeks or more
• Your blood counts and organ functions (such as liver and kidneys) are at acceptable levels
• You are willing and able to use contraception throughout the trial

Who may not be able to join:

• You have uncontrolled fluid build-up around your lungs, heart, or abdomen that is causing symptoms
• You have had or currently have another type of cancer
• You have a history of, or currently have, a lung condition involving scarring or inflammation (confirm with trial site)
• You have heart problems or heart disease that is not well controlled
• You have had a blood clot in an artery or vein before starting the trial
• You have had a significant bleeding event before starting the trial (confirm with trial site)
• You have had a hole or abnormal opening in your digestive tract, a urinary tract opening, or an infection/abscess in your abdomen before starting the trial
• You have a bowel blockage or are being fed through an intravenous line instead of eating normally
• You have had a serious infection before starting the trial
• You have active hepatitis B or hepatitis C infection
• You have received cancer treatment within 4 weeks before starting the trial
• You have previously been treated with a specific type of chemotherapy drug called a TOP1 inhibitor, or a drug that delivers a TOP1 inhibitor directly to cancer cells
• You still have significant side effects (grade 2 or higher) from a previous cancer treatment that have not resolved (confirm with trial site)
• You have had a severe allergic reaction to the study drug (SHR-A1921) or any of its ingredients
• The trial doctor has another reason they feel makes you unsuitable for the trial

⚠️ Important: Always verify eligibility with the trial site directly before applying.