Psoriasis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with chronic plaque psoriasis for at least 12 months before the screening visit.
• Your psoriasis is considered moderate to severe, based on at least one of the following measures used by your doctor (confirm with trial site).
• You have been prescribed (but have not yet started) one of these specific psoriasis medications: Secukinumab, Ixekizumab, Brodalumab, Guselkumab, Risankizumab, or Tildrakizumab — and you are willing to start one of them during the study.
• Apart from your psoriasis, you are in generally good health, as assessed by the study doctor based on your medical history and a physical check-up.
• You are considered eligible for a weight loss program, meaning you are in good general health and your body mass index (BMI — a measure of body weight relative to height) is between 25 and 40.

Who may not be able to join:

• You have a significant history of serious heart disease (such as having had a heart attack, blood clots, or a heart stent), inflammatory bowel disease, or other major uncontrolled health conditions affecting organs such as the lungs, liver, kidneys, or immune system.
• You have any condition that the study doctor believes would put you at risk by participating.
• You have another skin or inflammatory condition that might make it hard to assess the psoriasis results accurately.
• You have ever attempted suicide, or have had a serious psychiatric illness requiring a hospital stay in the last 3 years.
• You are currently pregnant or breastfeeding.
• You have already tried and not responded to more than 3 systemic (whole-body) treatments for psoriasis.
• You have a known allergy to any ingredient in the types of psoriasis medications used in this trial (Anti-IL-17 or Anti-IL-23 therapies).
• You have had a serious infection (such as pneumonia, hepatitis, or blood poisoning) or been hospitalised for an infection, unless you have been fully recovered for more than 4 weeks before screening.
• You have a history of ongoing or repeated infections, such as chronic chest infections, recurring urinary tract infections, or open/infected skin wounds or ulcers.
• You have received a BCG vaccination (a type of tuberculosis vaccine) within the past year.
• You have HIV, or a condition that weakens your immune system (either from birth or acquired).
• You have had a substance misuse problem within the past 6 months.
• You have needed antibiotics for a bacterial infection, or had a significant viral or fungal infection, within the past 4 weeks.
• You have a current or past history of cancer, with the exception of certain fully treated and cured skin cancers or a specific type of treated cervical condition with no recurrence in the past 5 years (confirm with trial site).
• You have a known nut allergy.
• You are currently taking part in a supervised diet program.
• You have used most psoriasis treatments (including creams, tablets, injections, or light therapy) within 2 weeks before the start of the study — though some limited exceptions apply (confirm with trial site for details).
• You have taken any experimental drug within 2 weeks before the start of the study.
• You have had prolonged sun exposure or used tanning beds or other UV light sources.
• Your psoriasis is currently flaring up or is unstable.

Important: Always verify eligibility with the trial site directly before applying.