Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older (and under 100 years old).
• People whose new stroke symptoms began within 12 hours of being enrolled in the trial, and where treatment with the study blood pressure medication can also be started within that 12-hour window.
• People showing clinical signs of stroke, such as problems with speech, movement, thinking, vision, or awareness of one side of the body.
• People with a stroke severity score of 1 or higher on a standard medical assessment scale (called the NIHSS).
• People with a level of consciousness score of 5 or higher on a standard scale (called the GCS) at the time of enrollment.
• People whose brain CT scan shows a blood clot within the brain tissue that is larger than 5 cc in volume (not including very small bleeds).
• People whose blood pressure (the top number) is between 150 and 219 mmHg, confirmed on two readings taken 5 to 10 minutes apart.
• People (or their legal representative or surrogate) who are willing and able to sign a consent form before leaving the hospital, and who agree to follow-up visits at 90 and 180 days.
• People whose bleeding in the brain was caused by blood-thinning medications, as long as steps to reverse those medications are being taken at the same time, in line with current medical guidelines.
• People who are expected to have surgical removal of the blood clot, as long as that surgery is not planned to happen within 6 hours of starting the study blood pressure medication.
• People who need a drain placed in the brain to relieve pressure, in line with current medical guidelines.

Who may not be able to join:

• People where the time their symptoms started cannot be reliably determined.
• People with a known brain tumour, abnormal blood vessel tangle (AVM), or brain aneurysm.
• People whose brain bleed is believed to have been caused by a head injury.
• People whose brain bleed is located in certain deep brain areas called the pons or midbrain (a bleed in the cerebellum does not automatically exclude someone — confirm with trial site).
• People whom the neurosurgery team considers to need immediate surgery.
• People who are pregnant, have given birth in the last 30 days, or are currently breastfeeding.
• People with a history of a bleeding disorder or blood clotting problems, unless the brain bleed was caused by blood-thinning medications.
• People with a platelet count below 50,000/mm³ (platelets are cells that help the blood clot).
• People with a known allergy or sensitivity to the medications nicardipine or clevidipine.
• People whose advance care document (living will) states they do not want intensive medical care in an ICU setting.
• People with allergies to soybeans, soy products, eggs, or egg products.
• People with certain conditions affecting how the body processes fats, such as abnormal fat metabolism disorders, a specific kidney condition called lipoid nephrosis, or acute inflammation of the pancreas combined with high fat levels in the blood.
• People with a severe narrowing of the main heart valve (severe aortic stenosis).

Important: Always verify eligibility with the trial site directly before applying.