Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who choose to take part voluntarily and have signed a consent form.
• Women aged 18 or older.
• People who have been diagnosed with primary breast cancer confirmed by a tissue or cell sample test.
• People whose cancer has been clinically diagnosed as having spread to a specific group of lymph nodes near the collarbone (classified as cN3c).
• People who have received treatment given before surgery (called neoadjuvant therapy), as directed by their doctor and current treatment guidelines.
• People whose cancer in the collarbone lymph node area did not fully disappear after neoadjuvant therapy.
• People who are having surgery with the goal of curing their breast cancer after neoadjuvant therapy.
• People whose lymph nodes under the arm were examined by a pathologist after surgery.
• People who have a functional wellbeing score of 80 or above (on a standard medical scale) and are expected to live more than 2 years (confirm with trial site).
• People whose surgical wound has fully healed without any complications.
• People whose surgical margins came back negative, meaning no cancer cells were found at the edges of the removed tissue.
• People for whom hormone receptor results (ER/PR), HER2, and Ki-67 test results are available for the breast tumour.
• Women who have not yet reached menopause and who have been using contraception for at least one month before the screening visit, and who will continue to do so throughout the study and for a set period after it ends.

Who may not be able to join:

• People whose cancer has been confirmed by tests or scans to have spread to other parts of the body.
• People who did not receive systemic treatment before surgery (neoadjuvant therapy).
• People who have not had surgery aimed at curing their cancer.
• People who are pregnant or currently breastfeeding.
• People who have serious non-cancer health conditions that would make receiving radiation therapy unsafe or impractical.
• People who have had another cancer in the past 5 years, with some exceptions such as certain early-stage or non-invasive cancers including ductal carcinoma in situ, basal cell skin cancer, early squamous cell skin cancer, cervical carcinoma in situ, or early lung adenocarcinoma.
• People who have breast cancer in both breasts at the same time.
• People who have previously had radiation therapy to the neck, chest, or the armpit area on the same side as the current cancer.
• People who have an active connective tissue disease affecting blood vessels (confirm with trial site).
• People whose primary tumour has been classified as T4 stage (confirm with trial site).
• People who are not able to begin radiation therapy within 12 weeks of breast cancer surgery, or within 8 weeks of finishing additional chemotherapy after surgery.

Important: Always verify eligibility with the trial site directly before applying.