Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Sub-Project 1 – Healthy volunteers:

• Adults aged 18 or older.
• People confirmed to be right-handed based on a standard handedness questionnaire called the Edinburgh Handedness Inventory.

Sub-Project 1 – Stroke survivors (more than 6 months post-stroke):

• Adults aged 18 or older.
• People who have been diagnosed with a stroke.
• People whose stroke occurred more than 6 months ago.
• People who have weakness on one side of the body as a result of their stroke.

Sub-Project 2 – Stroke survivors (between 7 days and 6 months post-stroke):

• Adults aged 18 or older.
• People who have been diagnosed with a stroke.
• People whose stroke occurred between 7 days and 6 months ago.
• People who have weakness on one side of the body as a result of their stroke.
• People whose recovery of arm and hand movement on the affected side falls within a moderate range on a standard medical scale (Brunnstrom stages III to V — confirm with trial site).
• People who do not have severe muscle stiffness in any part of the affected arm, as measured by a standard clinical scale (Modified Ashworth Scale score of 2 or below — confirm with trial site).

Who may not be able to join:

Sub-Project 1 – Healthy volunteers:

• People with a history of neurological conditions (such as stroke, brain tumour, or epilepsy), psychiatric conditions (such as major depression, schizophrenia, bipolar disorder, or substance use disorders), or musculoskeletal problems affecting the upper limb.
• People with medical reasons that prevent safe use of mild electrical brain stimulation, including a history of epilepsy, an irregular heart rhythm condition called atrial fibrillation, metal implants in the body, a cardiac pacemaker, skull defects, or raised pressure inside the skull.
• People with skin allergies, contact dermatitis, unusual pain sensitivity, wounds, or ulcers on the head.
• People currently taking part in other studies involving brain stimulation (invasive or non-invasive).
• Women who are pregnant or breastfeeding; women of childbearing potential must have a negative pregnancy test, and both male and female participants who could father or conceive a child must agree to use effective contraception during the trial and for 4 months after the last dose of any investigational treatment (confirm with trial site).
• People with a history of alcohol or substance misuse.
• People with damaged skin at the area where stimulation devices or electrodes would be placed.
• People who take long-term medications that affect the brain or nervous system (such as antidepressants or sedatives) or any medications that may lower the threshold for seizures.
• People whose doctor considers them unsuitable for electrical or magnetic brain stimulation for any other reason.
• People affiliated with certain research institutions, such as students from NTU or Taipei Medical University.

Sub-Project 1 – Stroke survivors (more than 6 months post-stroke):

• People with medical reasons that prevent safe use of mild electrical brain stimulation, including a history of epilepsy, atrial fibrillation, metal implants, a cardiac pacemaker, skull defects, or raised pressure inside the skull.
• People with skin allergies, contact dermatitis, unusual pain sensitivity, wounds, or ulcers on the head.
• People with serious neurological or psychiatric conditions other than stroke, such as major depression, schizophrenia, substance use disorders, Parkinson's disease, or brain tumours.
• People taking medications that may lower the threshold for seizures.
• People currently receiving other brain stimulation therapies (invasive or non-invasive).
• Women who are pregnant or breastfeeding; women of childbearing potential must have a negative pregnancy test, and both male and female participants who could father or conceive a child must agree to use effective contraception during the trial and for 4 months after the last dose of any investigational treatment (confirm with trial site).
• People with a history of alcohol or substance misuse.
• People with damaged skin at the area where stimulation devices or electrodes would be placed.
• People who take long-term medications that affect the brain or nervous system (such as antidepressants or sedatives) or any medications that may lower the threshold for seizures.
• People whose doctor considers them unsuitable for electrical or magnetic brain stimulation for any other reason.

Sub-Project 2 – Stroke survivors (between 7 days and 6 months post-stroke):

• People with medical reasons that prevent safe use of mild electrical brain stimulation, including a history of epilepsy, atrial fibrillation, metal implants, a cardiac pacemaker, skull defects, or raised pressure inside the skull.
• People with skin allergies, contact dermatitis, unusual pain sensitivity, wounds, or ulcers on the head.
• People with serious neurological or psychiatric conditions other than stroke, such as major depression, schizophrenia, substance use disorders, Parkinson's disease, or brain tumours.
• People taking medications that may lower the threshold for seizures.
• People with other muscle or joint problems that affect arm function, such as joint contractures, rheumatoid arthritis, or a condition called myositis ossificans.
• People with severe difficulties in thinking or understanding that would make it hard to follow instructions, or who have a type of communication difficulty (called receptive or global aphasia) that affects their understanding of spoken or written language.
• People who have a condition called hemineglect, where the brain has difficulty paying attention to one side of the body or environment (including visual, hearing-related, or sensory forms).
• People currently receiving other brain stimulation therapies (invasive or non-invasive).
• Women who are pregnant or breastfeeding; women of childbearing potential must have a negative pregnancy test, and both male and female participants who could father or conceive a child must agree to use effective contraception during the trial and for 4 months after the last dose of any investigational treatment (confirm with trial site).
• People with a history of alcohol or substance misuse.
• People with damaged skin at the area where stimulation devices or electrodes would be placed.
• People who take long-term medications that affect the brain or nervous system (such as antidepressants or sedatives) or any medications that may lower the threshold for seizures.
• People whose doctor considers them unsuitable for electrical or magnetic brain stimulation for any other reason.

Important: Always verify eligibility with the trial site directly before applying.