Phase 2 Oesophageal Cancer Trial, Recruiting NCT06421376 Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Condition: Oesophageal Cancer
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Phase 2 Oesophageal Cancer Trial, Recruiting

NCT06421376
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are between 18 and 80 years old
  • You have been diagnosed with esophageal squamous cell carcinoma (a specific type of esophageal cancer), confirmed by a tissue sample/biopsy
  • Your cancer is at a locally advanced stage, meaning it may have spread to nearby lymph nodes, including possibly the lymph nodes above the collarbone, but not to distant parts of the body — as confirmed by CT scan and/or internal ultrasound
  • You are able to carry out daily activities mostly or fully on your own (confirm with trial site)
  • Your blood counts, liver function, and kidney function are within acceptable healthy ranges as shown by recent blood tests

Who may not be able to join:

  • You have, or have had, another type of cancer (except previously cured skin basal cell carcinoma or cervical carcinoma in situ)
  • You have already received previous treatment for this cancer
  • Your cancer has spread to distant parts of the body such as bones, brain, lungs, liver, or abdomen, or you have fluid build-up in the chest or abdomen due to cancer
  • Your esophagus has already perforated (developed a hole) or is at high risk of doing so
  • Your tumor is growing very close to major blood vessels, creating a risk of serious bleeding
  • You currently have an active infection, such as active tuberculosis or hepatitis
  • You have a medical reason why you cannot receive immunotherapy (confirm with trial site)
  • You are pregnant, breastfeeding, or of childbearing age and not using reliable contraception
  • You have serious heart problems, such as uncontrolled heart failure, coronary artery disease, irregular heartbeat, uncontrolled high blood pressure, or you have had a heart attack in the last 6 months — or you have other serious uncontrolled conditions such as diabetes or high blood pressure
  • Your situation does not meet the trial's requirements for other medical reasons, as judged by the research team

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Xin Wang, Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)

Phone: +8601087787635

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Registry
ClinicalTrials.gov
Start date
1 May 2024
Est. completion
31 December 2026

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Event-free survival

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov