Phase 1 Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 65 years old (inclusive) at the time of the screening visit
• People with a body mass index (BMI) between 18.5 and 32.0, and who weigh at least 50 kg at screening
• Non-smokers, or former smokers who have smoked no more than 100 cigarettes in their entire lifetime and have not used any tobacco or tobacco-containing products for at least 3 months before screening
• Women who are not pregnant or breastfeeding, and who agree to use two highly effective forms of contraception from screening until 3 months after the last dose of the study treatment

Who may not be able to join:

• People who are allergic or sensitive to any ingredients in the study treatment
• People with a history of, or currently experiencing, unexplained bleeding, coughing up blood, unusual bleeding tendencies, or blood clotting disorders
• People with a history of, or currently experiencing, asthma, sleep apnea, COPD (a chronic lung condition), pulmonary fibrosis, bronchiectasis, bronchospasm, or reactive airway disease — though people whose childhood asthma has fully resolved may be considered (confirm with trial site)
• People with a history of, or currently experiencing, heart attack, stroke, coronary artery disease, unstable chest pain, heart failure, significant irregular heartbeat, heart valve disease, suspected fluid in the lungs, or a type of high blood pressure affecting the lungs caused by blood clots
• People whose blood pressure reading at screening or check-in falls outside an acceptable range — specifically, top number below 90 or above 140, or bottom number below 50 or above 95
• People whose lung function tests or resting blood oxygen levels fall below acceptable levels at screening or check-in (confirm with trial site for specific values)
• People with a history of drug or alcohol misuse in the year before check-in, or those who regularly drink more than 14 standard drinks per week (for women) or more than 21 standard drinks per week (for men)
• People who have consumed caffeine, poppy seeds, or alcohol within 48 hours before dosing, or grapefruit or pomelo within 10 days before dosing, or those unwilling to avoid alcohol from 48 hours before dosing through to Day 14
• People who have received blood products within 2 months before dosing
• People who test positive for HIV, hepatitis B, hepatitis C, or pregnancy
• People who have donated blood or had significant blood loss (more than 480 ml) within 3 months before screening
• People unwilling to avoid intense physical exercise from 7 days before dosing until the end of the study
• People planning to get a tattoo, body piercing, or any invasive procedure during the study period

Important: Always verify eligibility with the trial site directly before applying.