Phase 1 Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are male or female, aged 18 to 65 years old at the time of screening.
• You weigh at least 50 kg (about 110 lbs) at the time of screening.
• Your Body Mass Index (BMI) — a measure of body weight relative to height — is between 19.0 and 35.0 at the time of screening.
• You have a documented history of asthma for at least 6 months.
• You have been on one of the following stable asthma treatments for at least 12 weeks before screening: a short-acting reliever inhaler only; a low-dose daily steroid inhaler (with or without a reliever inhaler); or a low-dose daily steroid inhaler combined with a long-acting reliever inhaler (with or without a short-acting reliever inhaler).
• You have not had a severe asthma attack in the past 6 months, and no more than one severe attack in the past 12 months.
• Your lung function test (a breathing test called FEV1) shows your lungs are working at 80% or more of what is expected for someone your age and size.
• You show a certain level of airway sensitivity during a specific breathing challenge test using a substance called methacholine (confirm with trial site).
• You are able to stop using your short-acting reliever inhaler for at least 12 hours, and your long-acting inhaler for at least 48 hours, before certain study visits.
• If you are a woman, you are not pregnant or breastfeeding, and either cannot become pregnant or are using a highly effective method of contraception.
• You are willing and able to sign a consent form agreeing to the study's requirements.
• You are a non-smoker and have not used any tobacco products in the past 12 months, and have smoked fewer than 10 pack-years total in your lifetime (confirm with trial site).

Who may not be able to join:

• You have a history of life-threatening asthma, or your asthma is currently considered unstable by a doctor.
• You have a history of other lung or breathing conditions, such as chronic bronchitis, emphysema, cystic fibrosis, pulmonary fibrosis, tuberculosis, or similar conditions.
• You have asymptomatic gallstones (gallstones that are not causing symptoms).
• You have a current or past history of blood, nerve, psychiatric, or other health conditions that a doctor feels could put you at risk during the study.
• You have had recent eye surgery, or have any condition where forceful breathing out could be harmful to you (confirm with trial site).
• You are currently taking a type of medication called a cholinesterase inhibitor (for example, a medication used to treat a condition called myasthenia gravis).
• You have taken part in more than 4 experimental drug studies in the past 12 months, or have been in another clinical trial within the past 30 days (or longer, depending on the study drug used).
• You currently work night shifts, or have worked night shifts in the past 15 days.
• You regularly drink more than 21 units of alcohol per week (if male) or more than 14 units per week (if female) within the past 6 months.
• You test positive for recreational drugs (including cannabis/THC) at screening.
• You have smoked cigarettes, cigars, pipes, or used any vaping or nicotine products within the past 12 months.

Important: Always verify eligibility with the trial site directly before applying.