Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a specific type of esophageal cancer (squamous cell carcinoma) located in the chest area, confirmed by a tissue biopsy, at a stage that has not spread to distant parts of the body
• Your doctors believe surgery could completely remove the cancer (with clear margins)
• You are generally able to carry out daily activities with little to no restriction (feeling well or only mildly limited)
• You are between 18 and 75 years old
• Your blood counts are healthy enough without needing transfusions or extra medications: enough white blood cells, infection-fighting cells, platelets, and red blood cells
• A specialist has confirmed your lungs and heart are working well enough, with no severe breathing problems or acute heart failure
• Your liver is functioning well, based on blood test results within acceptable ranges
• Your kidneys are functioning well, based on blood test results within acceptable ranges
• You are willing to take part voluntarily, sign a consent form, and attend all required visits and follow all study procedures
• Your doctors expect you to live longer than 6 months
• You agree to have surgery, radiation therapy, chemotherapy, and immunotherapy as part of the trial
• If you could become pregnant, you have had a negative pregnancy test within 7 days before starting treatment; all participants agree to use effective contraception during the trial and for 8 weeks after the last dose
• You do not have a hole (perforation) or active bleeding in your esophagus, and the cancer has not grown into your windpipe or major chest blood vessels
• You have at least one area of cancer that can be measured on a scan

Who may not be able to join:

• You are not suitable for the specific immunotherapy or chemotherapy drugs used in this trial (confirm with trial site)
• You have previously received any treatment for this esophageal cancer, including chemotherapy, radiotherapy, experimental drugs, or certain immune checkpoint therapies (such as anti-PD-1 or anti-PD-L1 drugs)
• Your cancer has previously caused an abnormal passage (fistula) to form
• Your doctors believe you are at high risk of developing a fistula or signs of a hole forming in the esophagus
• You have needed high-dose steroid tablets or other immune-suppressing medicines in the 14 days before starting the trial (some low-dose or short-term steroid use may still be acceptable — confirm with trial site)
• You have an active autoimmune disease (where your immune system attacks your own body), or a history of one that could come back — though some well-controlled conditions like type 1 diabetes, an underactive thyroid, or certain skin conditions may still be eligible (confirm with trial site)
• You have a history of scarring lung disease, non-infectious lung inflammation, or poorly controlled lung conditions such as pulmonary fibrosis
• You currently need antibiotics, antifungal, or antiviral treatment for an active infection such as tuberculosis, or you have had a serious infection requiring hospitalisation in the past 4 weeks, or have taken antibiotic tablets or drips in the past 2 weeks
• You have previously had an organ transplant (other than a cornea transplant) or a bone marrow/stem cell transplant from another person
• You are known to be allergic to the study drug (tiragolumab) or to any of the chemotherapy drugs used in this trial
• You have significant heart problems such as serious irregular heartbeat, heart block, unstable chest pain, or heart failure affecting your daily life

Important: Always verify eligibility with the trial site directly before applying.