Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are over 50 years of age
• People who are expected to live for at least 10 more years
• People who have been diagnosed with prostate cancer through a tissue sample (biopsy), where the cancer is contained within the prostate and is at a clinical stage of T2c or lower
• People whose PSA level (a blood marker for prostate cancer) is 15 ng/mL or below, or whose PSA density is below 0.15 ng/mL² if their PSA is above 15 ng/mL
• People whose prostate cancer has a Gleason score of 3+4 or 4+3 (a measure of how the cancer cells look under a microscope)
• People whose MRI scan shows no signs of the cancer spreading outside the prostate gland
• People whose MRI scan shows no signs of the cancer reaching the seminal vesicles (small glands near the prostate)
• People whose prostate gland can be clearly seen by the treating doctor using ultrasound during biopsy
• People who have had a specific type of targeted prostate biopsy (guided by MRI findings), plus a wider systematic biopsy of 10–14 samples, confirming a Gleason score of 7 only in the area identified on MRI, with no Gleason 7 or higher cancer found outside that area
• People who have a lesion (abnormal area) visible on MRI that can be reached by the Irreversible Electroporation (IRE) treatment used in this trial (confirm with trial site for details about nearby biopsy findings)
• People who are willing and able to sign a consent form agreeing to take part
• People who are able and willing to attend all required follow-up appointments

Who may not be able to join:

• People who have a known allergy or sensitivity to pancuronium bromide, atracurium, or cisatracurium (medicines used to relax muscles during procedures)
• People who are not suitable for general anaesthesia or cannot receive the muscle-relaxing medicines used in this trial
• People who currently have a urinary tract infection (UTI)
• People who have a history of bladder neck contracture (scarring that narrows the bladder opening)
• People who wish to have children in the future
• People who have had inflammatory bowel disease within the past 3 years
• People who have another serious or debilitating illness at the time of the trial
• People who have received active treatment for any cancer (other than prostate cancer or non-melanoma skin cancer) within the past 3 years — people considered to be in remission for at least 3 years by their cancer care provider may be eligible (confirm with trial site)
• People who have any active implanted electronic device, such as a pacemaker
• People who are unable or unwilling to use a urinary catheter (a tube used to drain the bladder)
• People who have previously received any treatment for prostate cancer, including biological therapy, chemotherapy, hormone therapy (within three months of the procedure), radiation therapy, or surgery for prostate cancer
• People who have previously had surgery for urethral stricture (narrowing of the urine tube), a urethral stent, or any implants placed in the prostate
• People who have had major surgery on the rectum in the past (other than for haemorrhoids)
• People who are not suitable for a pelvic MRI scan — for example, due to severe claustrophobia, a permanent pacemaker, certain metal implants that would interfere with imaging, or an allergy or other reason they cannot receive gadolinium (a contrast dye used to enhance MRI images)

Important: Always verify eligibility with the trial site directly before applying.