Stroke Trial, Recruiting NCT06458153 Sponsor: University of Pittsburgh Condition: Stroke
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Stroke Trial, Recruiting

NCT06458153
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

Group 1 – Neurotypical adults (no neurological conditions):

  • Adults aged 18 to 49
  • Right-handed people
  • Native English speakers

Group 2 – People with cerebellar lesions:

  • Adults aged 18 or older
  • Right-handed people
  • Native English speakers
  • People with a history of a stroke affecting the cerebellum (a part of the brain at the back of the skull)

Group 3 – General comparison group (matched to Group 2):

  • Adults aged 18 or older
  • Right-handed people
  • Native English speakers

Who may not be able to join:

Group 1 – Neurotypical adults:

  • People who have metal implants, pacemakers, neurostimulators, a metal-containing intrauterine device, or who have had shrapnel injuries, as these create safety risks in MRI scanners
  • People with a history of a neurological or neurodegenerative disease, or a severe brain injury such as a stroke or serious head trauma
  • People with hearing loss measured above 25 decibels at standard test frequencies (confirm with trial site)
  • People who have been diagnosed with or treated for schizophrenia or another psychotic disorder
  • People who have been diagnosed with or treated for a neurocognitive disorder such as dementia or delirium
  • People with a severe, unmanaged, clinically diagnosed attention disorder
  • People who have been diagnosed with or treated for a speech, language, or hearing disorder
  • People with a head circumference greater than 60cm or a body weight greater than 300 pounds
  • People with a history of severe claustrophobia (intense fear of enclosed spaces)
  • People who are currently pregnant or possibly pregnant

Group 2 – People with cerebellar lesions:

  • People who have metal implants, pacemakers, neurostimulators, a metal-containing intrauterine device, or who have had shrapnel injuries, as these create safety risks in MRI scanners
  • People with a history of a neurological or neurodegenerative disease, or a severe brain injury other than stroke
  • People with hearing loss measured above 50 decibels at standard test frequencies (confirm with trial site)
  • People who have been diagnosed with or treated for schizophrenia or another psychotic disorder
  • People who have been diagnosed with or treated for a neurocognitive disorder such as dementia or delirium
  • People with a severe, unmanaged, clinically diagnosed attention disorder
  • People with a head circumference greater than 60cm or a body weight greater than 300 pounds
  • People with a history of severe claustrophobia
  • People who are currently pregnant or possibly pregnant

Group 3 – General comparison group:

  • People who have metal implants, pacemakers, neurostimulators, a metal-containing intrauterine device, or who have had shrapnel injuries, as these create safety risks in MRI scanners
  • People with a history of a neurological or neurodegenerative disease, or a severe brain injury such as a stroke or serious head trauma
  • People with hearing loss measured above 50 decibels at standard test frequencies (confirm with trial site)
  • People who have been diagnosed with or treated for schizophrenia or another psychotic disorder
  • People who have been diagnosed with or treated for a neurocognitive disorder such as dementia or delirium
  • People with a severe, unmanaged, clinically diagnosed attention disorder
  • People who have been diagnosed with or treated for a speech, language, or hearing disorder
  • People with a head circumference greater than 60cm or a body weight greater than 300 pounds
  • People with a history of severe claustrophobia
  • People who are currently pregnant or possibly pregnant

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 12 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Jason W Bohland, Ph.D., University of Pittsburgh

Phone: 412-383-3416

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
27 May 2025
Est. completion
1 July 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech; BOLD responses related to pre-speech auditory modulation; EEG responses to self vs. externally generated speech; BOLD responses to induced auditory errors; BOLD responses during adaptation to auditory perturbations; BOLD responses during learning of non-speech auditory motor targets

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 12 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov