Phase 3 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of ovarian, peritoneal, or fallopian tube cancer — confirmed by laboratory testing — including high-grade serous, endometrioid, or carcinosarcoma (with at least 30% epithelial tumour component) types.
• People who are 18 years of age or older.
• People whose cancer is at an advanced stage (Stage III or IV).
• People who have already received 3 to 4 rounds of standard pre-surgery chemotherapy (carboplatin and paclitaxel, given every 3 weeks), whose CA-125 blood marker results showed a poor response to that chemotherapy (a KELIM score below 1.0), and whose cancer was not able to be fully removed by surgery.
• People with a good general level of physical functioning — rated 0 or 1 on a standard medical scale, meaning fully active or able to carry out light activity (confirm with trial site).
• People whose blood counts are at acceptable levels, including haemoglobin, white blood cells, and platelets, without having needed a blood transfusion in the 3 weeks before testing.
• People whose kidneys and liver are functioning at adequate levels, as measured by specific blood tests (confirm specific values with trial site).
• People who are willing and able to attend all required treatment sessions, appointments, and follow-up visits for the full duration of the trial.
• People who have signed a written consent form agreeing to take part in the study.
• People who are covered by a social insurance or healthcare scheme.

Who may not be able to join:

• People whose cancer is a low-grade, clear cell, mucinous, or certain other specific tumour types, or those who have a known allergy or medical reason preventing the use of carboplatin, paclitaxel, or GCSF (a drug used to support white blood cell levels).
• People who received bevacizumab (a targeted therapy) as part of their initial pre-surgery chemotherapy.
• People whose cancer continued to grow or spread during their pre-surgery chemotherapy, indicating it did not respond to platinum-based treatment.
• People who currently have another active cancer, unless it is a previously treated, non-melanoma skin cancer, fully treated cervical cancer in situ, or another cancer that was fully treated with no signs of return for 5 or more years.
• People who are currently taking part in another clinical trial involving an experimental treatment.
• People with serious uncontrolled health conditions, which may include unstable heart problems, a heart attack within the past 6 months, severe uncontrolled high blood pressure, serious heart rhythm problems, heart failure, liver cirrhosis, an active serious infection requiring intravenous antibiotics within the past 2 weeks, or certain bowel blockage or obstruction issues (confirm specific details with trial site).
• People with a known psychiatric condition that the trial team believes would affect their ability to follow the trial requirements.
• People who are pregnant, currently breastfeeding, or planning to have children during the period covered by the trial.
• People who are legally under guardianship, curatorship, or who are not free to make their own decisions (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.