Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of prostate cancer (adenocarcinoma or poorly differentiated carcinoma) confirmed by laboratory testing of tissue — note that cancers made up entirely of small-cell or high-grade neuroendocrine cells are not eligible, though some neuroendocrine features are allowed.
• People whose testosterone levels have been reduced to very low levels (≤ 50 ng/dL) either through surgery to remove the testicles or through ongoing hormone-blocking medication, which must be continued throughout the study.
• People whose cancer has continued to grow or spread despite previous treatment, shown by at least one of: two rising PSA blood test results taken at least one week apart (with the most recent being ≥ 2 ng/mL), new or growing tumours visible on a CT or MRI scan, or at least two new areas of cancer detected on a bone scan.
• People who have signed an informed consent form before any study-related procedures begin.
• People aged 18 years or older.
• People with a life expectancy of at least 3 months.
• People with a good general health and activity level, rated 0 or 1 on a standard performance scale (confirm with trial site).
• People whose blood, liver, and kidney function results fall within the ranges required by the trial (confirm with trial site for specific values).

Who may not be able to join:

• People who have had significant surgery to remove part of the stomach or small intestine, or who have a condition that affects the body's ability to absorb food or medication taken by mouth.
• People with serious ongoing physical or mental health conditions that the trial doctor considers incompatible with participation.
• People with an active infection at the time of joining, as assessed by the trial doctor.
• People with conditions affecting the brain or nervous system — including epilepsy or significant confusion — that would prevent them from understanding the consent process or completing study procedures.
• People currently taking a specific class of medications known as cationic amphiphilic drugs, including some that are available without a prescription (confirm with trial site for the full list).
• People currently taking another experimental drug as part of a different trial or study.
• People who have had an allergic reaction to any of the medications used in this trial.

Important: Always verify eligibility with the trial site directly before applying.