Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with invasive breast cancer that has spread to other parts of the body (metastatic), confirmed by a tissue test
• People whose treating doctor considers them a candidate for a type of cancer treatment called a PARP inhibitor, either alone or combined with another type of treatment called an immune checkpoint inhibitor (ICI)
• People who have at least one area of disease that can be measured or assessed using a CT or MRI scan at the start of the study
• People aged 18 or older
• People who are well enough to carry out daily activities to a certain minimum level, as measured by standard medical performance scales (confirm with trial site)
• People who have stored tissue samples from a biopsy of a site where the cancer has spread, taken before joining the study — or who are willing to have a new biopsy taken during the screening period if no stored sample is available
• People who are willing to have a biopsy of a cancer site during treatment, if a special scan called an [18F]FTT PET scan is performed around 12 weeks after starting treatment
• Women who could become pregnant must have a negative blood pregnancy test within 7 days before each [18F]FTT PET scan
• People who are willing to use two reliable forms of contraception throughout the study
• People who are willing and able to attend all required visits and follow the study schedule for its full duration
• People who are able to understand the study and are willing to sign a written consent form before any study procedures begin

Who may not be able to join:

• People who have previously been diagnosed with certain blood or bone marrow disorders called myelodysplastic syndrome or acute myeloid leukaemia
• Women who are pregnant or breastfeeding
• People who have a known allergic reaction or sensitivity to the specific PARP inhibitor being used in the trial
• People who have serious uncontrolled health conditions, such as an active infection, severe heart problems, or a psychiatric or social situation that would make it difficult to follow the study requirements
• People who are unable to swallow tablets or capsules, or who have digestive system conditions that may prevent the PARP inhibitor from being properly absorbed by the body (as determined by the investigating doctor)

Important: Always verify eligibility with the trial site directly before applying.