Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give written consent and follow the study's rules and schedule
• You are a woman aged 18 or older
• You have been diagnosed with a specific type of advanced ovarian, fallopian tube, or peritoneal cancer (high-grade serous or high-grade endometrioid, at an advanced stage known as FIGO Stage IIIB/C or IV)
• Your cancer spread (including in the abdomen) is considered removable by surgery with no tumour left behind
• Any side effects from previous cancer treatment have mostly cleared up (hair loss is an exception)
• Your tumour has been tested and confirmed to be "HR proficient" (a specific tumour characteristic — confirm with trial site)
• You have received chemotherapy before surgery (NACT), and your cancer has stayed stable or shrunk, and doctors think you are suitable for surgery
• You are well enough to have the surgery and follow-on treatment, based on a standard fitness scale (ECOG score of 0–2)
• Your kidneys are working well enough, based on a blood/urine test result
• Your liver is working well enough, based on blood test results
• Your blood counts (white blood cells, platelets, and haemoglobin) meet minimum levels shown in blood tests
• If you could become pregnant, you have a negative pregnancy test before joining the trial
• If you could become pregnant, you agree to use a highly effective form of contraception during treatment and for at least 9 months afterwards (specific methods are listed — confirm with trial site)

Who may not be able to join:

• You have a known BRCA1 or BRCA2 gene mutation, or your tumour is confirmed to be "HR deficient" (confirm with trial site)
• There is concern that the study drug may not stay where it should in your body after being given (confirm with trial site)
• Your cancer is a specific type not covered by this trial, such as borderline tumours, clear cell, mucinous, or certain other rare types, or your cancer has come back after previous treatment
• You have cancer that has spread to the brain and is causing symptoms
• You have had another cancer in the past 3 years (some exceptions apply, such as certain early-stage skin or cervical cancers — confirm with trial site)
• You have previously had radiotherapy to your abdomen or pelvis
• Your cancer got worse during the chemotherapy given before surgery
• You are pregnant or breastfeeding
• You have an active infection currently being treated with antibiotics or causing recurring fevers
• You have active hepatitis B, hepatitis C, or HIV
• You have heart failure or a significant heart condition (NYHA Class III or IV)
• You have any other health condition that the doctors feel could put you at risk or affect the study results
• In the doctor's opinion, you are unable to follow the study procedures or give proper informed consent
• You have taken part in another drug trial within the past 4 weeks (or within a specific time window based on that drug — confirm with trial site)
• You have received other cancer treatments within 4 weeks before or after the planned surgery
• You have been treated with a drug called bevacizumab within 5 weeks before surgery
• You have a known allergy to any ingredient in the study drug

Important: Always verify eligibility with the trial site directly before applying.