Stroke Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have had an acute ischemic stroke (a stroke caused by a blockage) affecting the back part of the brain, where symptoms started or the person was last seen well between 24 and 72 hours ago (not including cases where the only symptom is dizziness/vertigo)
• People who either could not receive clot-dissolving medication given through a vein (IV), had a reason it was not safe for them, or received it but the blockage did not clear
• People whose brain imaging (CT, MRI, or similar scan) confirms a blockage in the basilar artery or both vertebral arteries inside the skull
• People aged 18 to 80 years old
• People whose stroke severity score (a standard neurological assessment called NIHSS) was 6 or higher before entering the trial
• People who had little to no disability before the stroke (confirm with trial site)
• People who can be treated within 72 hours of when symptoms started or when they were last seen well
• People (or their authorised representative) who have given informed consent to participate

Who may not be able to join:

• People with known bleeding disorders, clotting factor deficiencies, or who are on blood-thinning medication with levels above a certain threshold
• People with a very low platelet count (below 50,000/µL) at the start of the trial
• People whose blood sugar level is very low (below 50 mg/dL) or very high (above 400 mg/dL) at the start
• People with severely and persistently high blood pressure that cannot be brought down with standard medications
• People whose stroke severity could not be assessed by a neurologist or emergency doctor before sedation or a breathing tube was inserted
• People who had a seizure at the time of their stroke, which would prevent a baseline assessment from being completed
• People with a serious or terminal illness where life expectancy is less than one year
• People with a known severe allergic reaction (more than a skin rash) to contrast dye used in scans
• People who had their stroke within the first 48 hours after heart or blood vessel procedures, or major surgery
• People with significant kidney problems (creatinine level at or above 3 mg/dL)
• People who are pregnant, breastfeeding, or have a positive pregnancy test on admission
• People currently participating in another clinical trial involving an investigational drug or device that could affect this study
• People with known or suspected inflammation of the brain's blood vessels (cerebral vasculitis)
• People with a pre-existing neurological or psychiatric condition that would make it difficult to assess stroke-related outcomes — including people who are severely dependent on others for daily activities such as toileting, dressing, eating, or preparing meals
• People unlikely to be available for a follow-up appointment at 90 days (for example, people with no fixed address or overseas visitors)
• People where the investigating doctor believes participation would pose a significant risk to their safety
• People whose brain imaging shows a low early CT score for the back of the brain (pc-ASPECTS below 6) combined with a pons-midbrain-index of 3 or higher (confirm with trial site)
• People whose CT or MRI shows any bleeding in the brain (small microbleeds on MRI are allowed)
• People whose imaging shows a complete cerebellar stroke causing significant pressure on nearby brain structures
• People whose imaging shows complete loss of blood supply to both thalamus regions of the brain
• People where the blockage or narrowing in the arteries cannot be safely reached or treated with a device, or where the blood vessels are too twisted to allow the device to be used safely
• People with blockages in both the front and back parts of the brain's blood supply
• People with evidence of a brain tumour, except for a small, slow-growing type called a meningioma

Important: Always verify eligibility with the trial site directly before applying.