Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older, any gender
• People who have been confirmed by tissue testing to have CD20-positive marginal zone lymphoma (MZL), including MALT, SMZL, or NMZL subtypes
• People whose MZL has come back, gotten worse, or is not suitable for local treatment after having previously received local treatments such as surgery, radiation, Helicobacter pylori treatment, or hepatitis C treatment
• People with a physical fitness/activity level rated 0–2 on a standard scale used by doctors (meaning able to carry out daily activities, even if with some limitations)
• People whose doctor has determined that treatment is needed — for example, due to symptoms, low blood counts, risk of organ damage, large tumour mass, ongoing disease progression, or the person's own wish to be treated
• People whose blood counts and organ function meet specific minimum levels set by the trial (covering blood cell counts, liver function, kidney function, and blood clotting) (confirm with trial site)
• People expected to live at least 3 months or more
• People who are willing to sign a written consent form before the trial begins

Who may not be able to join:

• People who currently have, or have previously been diagnosed with, another cancer — unless they received treatment aimed at a cure and there has been no sign of return or spread in the last 5 years
• People whose lymphoma has spread to the brain or spinal cord, or whose lymphoma has changed into a more aggressive type
• People who have had active bleeding within the 2 months before screening, are currently taking blood-thinning medications, or whose doctor believes they have a clear tendency to bleed
• People who have had major surgery within 6 weeks before screening, or minor surgery within 2 weeks before screening
• People with an active infection, or uncontrolled hepatitis B, hepatitis C, HIV/AIDS, or other serious infectious diseases
• People with a mental health condition or cognitive difficulty that could affect their ability to understand or follow the study requirements
• Women who are pregnant or breastfeeding, or women of childbearing age who are not willing to use contraception during the trial
• People who need to continuously take certain medications that strongly affect how the body processes drugs through a liver enzyme called CYP3A (confirm with trial site which specific medications apply)
• People who the trial doctor considers unsuitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.