Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 75 years old.
• People who have been diagnosed with prostate cancer through a tissue or cell sample test, and whose doctors have determined that surgery to remove the prostate (radical prostatectomy) is an appropriate treatment option.
• People who are largely able to carry out daily activities with no more than mild limitations (based on a standard medical fitness scale called ECOG, with a score of 0 or 1).
• People who are able to complete specialised prostate imaging scans (mpMRI or 68Ga-PSMA PET/CT) both before and after the pre-surgery treatment phase.
• People whose cancer meets at least one of the following staging conditions: the imaging scans show the tumour has reached a certain size or has spread to nearby lymph nodes; the tumour has a Gleason score (a measure of cancer aggressiveness) of 8 or higher; or the PSA blood level (a prostate cancer marker) is 20 ng/ml or above.
• People whose blood tests and organ function results fall within acceptable ranges, as checked within 28 days before joining the trial (confirm specific values with the trial site).
• People who are willing to voluntarily sign a consent form and follow all study requirements.

Who may not be able to join:

• People whose cancer has spread to lymph nodes in or beyond the local area, to bones, or to other organs, based on clinical or scan findings.
• People who have previously received hormone therapy, surgery to remove hormone-producing organs, targeted local treatment, radiotherapy, or chemotherapy for prostate cancer.
• People with a severe or uncontrolled active infection.
• People with severe heart failure classified as Class III or IV by standard heart failure guidelines (New York Heart Association scale).
• People with uncontrolled severe high blood pressure, persistently uncontrolled diabetes, lung disease requiring ongoing oxygen use, chronic liver disease, or HIV infection.
• People with a mental illness, intellectual disability, or any condition that prevents them from being able to give informed consent.
• People who have had another type of cancer in the past 5 years, except for certain fully treated skin cancers (basal cell or squamous cell skin cancers that have been cured may still be considered eligible — confirm with the trial site).

Important: Always verify eligibility with the trial site directly before applying.