Motor Neurone Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older
• People who are able to understand and agree to participate in the study
• People who are willing to follow the study's procedures
• People who are a close family member (parent, child, or sibling) of someone known to carry a gene linked to ALS, OR a close family member of someone who had ALS or FTD in a family where at least 2 close relatives have had ALS or FTD (with at least one of those being ALS) — regardless of whether genetic testing has been done in the family
• People who have access to a smartphone, tablet, or computer with internet connection — this does not need to be at home, and access at a public library or similar location is considered sufficient

Who may not be able to join:

• People who are showing signs or symptoms that may suggest ALS or FTD, as assessed by the trial doctor (those people would be referred for appropriate medical follow-up)
• People with significant memory or thinking difficulties, dementia, or unstable mental health conditions — such as psychosis, active thoughts of suicide, a recent suicide attempt, or untreated major depression within the past 3 months — that the trial doctor believes would interfere with study participation
• People with a serious, unstable medical condition (such as heart instability, active widespread infection, untreated thyroid problems, or actively progressing cancer) that the trial doctor believes would make it unlikely the person could complete 12 months of follow-up

For the optional spinal fluid (lumbar puncture) procedure, additional criteria apply. People may not be able to take part in this optional procedure if they:

• Have a medical condition that makes a lumbar puncture unsafe, such as a bleeding disorder, a skin infection near the procedure site, or a condition causing increased pressure in the brain or spine (confirm with trial site)
• Have an allergy to lidocaine or similar local anaesthetic medications
• Are taking blood-thinning or anti-clotting medications (other than low-dose aspirin 81 mg) that cannot be safely stopped before the procedure
• Have a blood disorder or abnormal bleeding condition, or are on dialysis for kidney failure
• Are currently pregnant (based on self-report)
• Are assessed by the trial doctor as unlikely to be able to undergo the procedure more than once

For a sub-study involving genetic testing results, people may be eligible if they are:

• Aged 18 or older, able to provide informed consent, willing to follow study procedures, and already enrolled in the main PREVENT ALS Study

Important: Always verify eligibility with the trial site directly before applying.