Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 60 and 85 years old (male or female)
• You have been diagnosed with Alzheimer's disease in the mild to moderate range, confirmed by a standard memory test score between 14 and 24
• You are either taking a stable dose of an approved Alzheimer's medication (such as donepezil or memantine) for at least 30 days, or you are not taking any such medication
• You have a reliable person (such as a family member or caregiver) who sees you face-to-face at least 3 days a week and can help make sure you take the study medication
• You have had a brain scan (MRI or CT) done within the past year, or one can be arranged before the study begins

Who may not be able to join:

• You have a condition that makes a lumbar puncture (spinal tap) unsafe, such as increased pressure in the brain, a growth at the base of the brain, a bleeding disorder, or you take blood-thinning medications (other than aspirin)
• You have severe disease affecting the blood vessels in your brain
• You have had a major stroke in the past
• You have a known allergy or sensitivity to B-vitamins or nicotinic acid (a form of Vitamin B3)
• You have a history of abnormal liver test results or known liver disease
• You are currently taking Vitamin B3 in any form — including in multivitamins or energy drinks — unless you are able to stop taking it for at least 4 weeks before the study begins
• You have moderate or worse kidney disease (stage 2 or higher) (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.