Phase 3 Crohn's Disease and Colitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have a confirmed diagnosis of ulcerative colitis (UC)
• Your UC is considered moderately to severely active, based on a specific scoring system used by doctors
• You weigh at least 40 kilograms (about 88 pounds)
• You are up to date with bowel cancer screening, as recommended in your local area
• Previous treatments for UC (either standard or newer/advanced therapies) have not worked well enough, stopped working, or caused side effects you could not tolerate
• If you are male or female and able to have children, you must agree to follow the trial's specific contraception requirements during the study

Who may not be able to join:

• You currently have serious complications of UC, such as a severe flare-up affecting the whole colon or a dangerously swollen colon
• You have been diagnosed with Crohn's disease, indeterminate colitis, or other specific types of colitis (such as microscopic, ischemic, infectious, or radiation-related colitis)
• You have a stoma bag or an internal pouch created after bowel surgery
• You have been diagnosed with, or are suspected of having, a liver condition called primary sclerosing cholangitis
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study
• You have been found to have pre-cancerous cell changes or growths in your colon that have not been fully removed
• You have had a cancer diagnosis within the last 5 years (some exceptions may apply for certain minor, fully treated skin cancers or cervical changes — confirm with trial site)
• You have a current infection with certain viruses or bacteria, including C. difficile, CMV, HIV, Hepatitis B, or Hepatitis C
• You have active tuberculosis (TB), or latent (inactive) TB that has not been successfully or fully treated
• You have previously received or are currently taking certain medicines that are not allowed in this trial, including any treatment targeting a specific protein called TL1A (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.