Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with diffuse large B-cell lymphoma (a type of blood cancer), confirmed by a tissue sample (biopsy)
• You have not received any previous treatment for this cancer, including chemotherapy, targeted therapy, immunotherapy, or radiotherapy
• You have at least one measurable area of cancer that can be tracked during the trial
• Your cancer shows up on a specific type of scan (PET-CT scan), and any affected lymph node is larger than 1.5 cm
• Your cancer is classified as stage II, III, or IV
• You are reasonably functional in daily life — not severely limited by your illness (confirm with trial site)
• You are expected to live for at least 3 more months
• Your blood counts (white blood cells, platelets, and red blood cells) meet certain minimum levels before starting the trial
• Your liver and kidney function tests are within acceptable ranges
• Your blood clotting results are within acceptable ranges
• If you are a woman who could become pregnant, you must have a negative pregnancy test within one week of joining, and agree to use effective contraception from the start of the trial until at least 12 months after your last treatment
• You are willing and able to understand the study requirements and sign a consent form

Who may not be able to join:

• You have a specific subtype of large B-cell lymphoma that started in the brain/spinal cord, testicles, chest (mediastinum), or certain other rare subtypes (confirm with trial site)
• Your lymphoma developed from a previously existing slower-growing (indolent) lymphoma
• Your cancer is currently active in your brain or spinal cord
• You have previously had a stem cell transplant
• You have received any prior treatment for lymphoma, except for short-term or low-dose steroid use
• You have taken any cancer-related herbal medicines or traditional Chinese medicines within the 14 days before starting the trial
• You have a known allergy or sensitivity to the study drug or similar medications
• You are currently taking part in another interventional clinical trial within 4 weeks of starting this trial
• You currently have an active bacterial or viral infection requiring strong or intravenous (IV) medication
• You have a history of immune system deficiency, including HIV
• You have active hepatitis B or hepatitis C infection
• You currently have a syphilis infection
• You have a serious underlying health condition, or alcohol or drug dependency, that could interfere with the trial or make it hard to follow the treatment plan
• You have lung disease (interstitial lung disease) that currently requires treatment
• You have a history of serious heart problems, including dangerous heart rhythm problems, a heart condition affecting the electrical signals of the heart, heart attack, heart failure, stroke, or uncontrolled high blood pressure within the past 6 months (confirm details with trial site)
• You have had another type of cancer within the past 2 years, unless it was a localised cancer that has been fully cured (such as certain skin cancers or early cervical cancer)
• You have a psychological or mental health condition that may make it difficult to follow the trial schedule
• You are currently pregnant or breastfeeding
• The trial doctor considers you unsuitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.