Phase 2 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 40 years or older
• People who have had a minor stroke (with mild symptoms scored 5 or below on a standard medical scale) caused by reduced blood flow to the brain, where brain scans show either a single affected area with significant narrowing (50% or more) of a major blood vessel in or leading to the brain, or multiple affected areas linked to a buildup of fatty deposits in the arteries
• People who have had a TIA (sometimes called a "mini-stroke") assessed as high risk using a standard scoring tool, where brain scans show significant narrowing (50% or more) of a major blood vessel in or leading to the brain
• People whose symptoms began no more than 24 hours before starting the study treatment (based on the last time they were seen without symptoms)
• People who do not plan to become pregnant from the time of signing the consent form until 3 months after the last dose of the study drug
• People who are able and willing to provide written consent to participate

Who may not be able to join:

• People whose brain scans show bleeding, abnormal blood vessel formations, tumours, abscesses, or other non-stroke brain conditions
• People whose only symptoms are purely sensory (such as numbness), visual changes alone, or dizziness/vertigo alone, with no sign of stroke on brain scans
• People who had significant disability before the current stroke event (confirm with trial site)
• People who have a medical reason they cannot take anti-platelet (blood-thinning) medications
• People who clearly need to be on blood-thinning (anticoagulant) medication
• People who have been continuously taking two or more anti-platelet medicines for 3 or more days before enrolling
• People who have taken heparin or anticoagulant medicines within the 10 days before enrolling
• People who have received clot-dissolving treatment or a mechanical clot-removal procedure within the 24 hours before enrolling
• People with a history of bleeding in the brain or a condition called amyloid angiopathy (a disease affecting blood vessels in the brain)
• People with a history of a brain aneurysm (a bulge in a blood vessel in the brain)
• People diagnosed with, or suspected of having, a heart attack or acute coronary syndrome
• People with a history of asthma
• People considered to be at high risk of an abnormally slow heart rate
• People expected to need anti-inflammatory pain relief medicines (such as ibuprofen) for more than 5 days within the first 8 days of the study
• People who have had a stomach or intestinal bleed in the 3 months before enrolling, or major surgery in the 30 days before enrolling
• People whose minor stroke or TIA was caused by a medical procedure
• People who are expected to need a procedure to restore blood flow to the brain within the next 3 months, or who have surgery or an interventional procedure planned that would require stopping the study medication
• People with a serious non-heart-related illness where life expectancy is less than 3 months
• Women of childbearing age who have not used effective contraception and have a positive pregnancy test, or who are currently pregnant or breastfeeding
• People currently taking part in another study involving an experimental drug or device, or who have done so in the past 30 days
• People who are unable to understand or follow study procedures due to mental health, cognitive, or emotional conditions
• People with a low haemoglobin (red blood cell) level below 90g/L
• People with permanently uncontrolled high blood pressure (confirm with trial site)
• People considered by the study doctor to be unsuitable for the trial for any reason

Important: Always verify eligibility with the trial site directly before applying.