Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been identified as having Mild Cognitive Impairment (MCI) — a level of memory or thinking difficulty that is noticeable but does not severely affect daily life — based on concerns raised by themselves, a family member, or a doctor.
• People whose score on a standard memory and thinking test (called the MoCA) falls between 19 and 25, and who show specific difficulties with learning and remembering new information.
• People whose diagnosis of MCI meets specific guidelines set by the National Institute on Aging and Alzheimer's Association, linking it to Alzheimer's disease.
• People whose ability to carry out everyday activities is largely normal, as measured by a standard assessment tool called the Clinical Dementia Rating Scale (CDR).
• People aged 50 years or older.
• People who are taking certain memory-related medications (cholinesterase inhibitors and/or memantine) may be eligible, provided the dose has remained unchanged for at least the past 3 months.

Who may not be able to join:

• People who are unable to tolerate having blood drawn.
• People with severe claustrophobia (fear of enclosed spaces) that would prevent them from being in an MRI scanner — though people who cannot safely have an MRI for any reason may still be able to enrol without undergoing that part of the trial (confirm with trial site).
• People who have a pacemaker or certain metal implants that make MRI unsafe — though as noted above, MRI may not be required for all participants (confirm with trial site).
• People diagnosed with alcohol or substance use disorder within the past 12 months, according to standard psychiatric guidelines (DSM-5).
• People with an unstable medical condition, such as poorly controlled diabetes or high blood pressure.
• People with any history of stroke, seizures, multiple sclerosis (MS), or Lyme disease.
• People with difficulties walking, seeing, or hearing that, in the investigator's judgement, could interfere with completing study assessments.
• People who do not speak English at a level needed to complete the study assessments.
• People who have not completed at least a Grade 8 (Year 8) level of education, as required for the study assessments.
• People who are currently taking part in another clinical trial involving an investigational (unapproved) product.
• People with a history of significant agitation or aggression, or epileptic seizures.
• People with a current neurological condition affecting thinking or memory, other than Alzheimer's disease.
• People who have a known sensitivity to sunlight or visible light (such as polymorphous light eruption or solar urticaria).
• People with a history of frequent nosebleeds in the past 24 weeks, or who are currently taking blood-thinning medications such as warfarin or low molecular weight heparin.
• People with increased skin sensitivity at the area where treatment would be applied, including active cold sores in that area, a history of raised scarring (keloid formation), or use of retinoid-based treatments in the past month.
• People who are pregnant, breastfeeding, or planning to become pregnant.
• People who are currently undergoing any other infrared light therapy treatment.
• People who, for any other reason, the investigator considers to be at unacceptable risk from participating in the trial.

Important: Always verify eligibility with the trial site directly before applying.