Phase 1 Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older.
• You have been diagnosed with breast cancer confirmed by a biopsy, including invasive ductal, invasive lobular, or other rare types.
• Your breast cancer is at an intermediate to advanced stage (Stage IIA through IIIC) or has spread to other parts of the body (Stage IV).
• A team of cancer doctors (medical, surgical, and radiation specialists) has reviewed your case and decided that radiation treatment is appropriate for you.
• You have been referred for either standard palliative or curative radiation therapy using one of several specific dose schedules (confirm with trial site for the full list).
• You are able to understand the study information and give your written consent to participate.
• You weigh less than 140 kg (approximately 308 lbs).
• The area of your cancer that needs to be treated can be reached by the special ultrasound and MRI procedure used in this trial.
• You are able to communicate how things feel to you during the procedure.
• Your kidney function is within a normal or acceptable range, based on blood test results.

Who may not be able to join:

• You are pregnant or currently breastfeeding.
• You are unable to have an MRI scan with contrast dye (a special dye used to make images clearer).
• You have received certain chemotherapy drugs (anthracycline or taxane-based) within the past 5 days.
• You have metal implants or breast implants.
• You have a connective tissue disorder or a physical deformity affecting your muscles or skeleton.
• The area of cancer to be treated has deep open wounds, bleeding, or discharge on the skin above it.
• There is scar tissue along the path where the ultrasound treatment would be directed.
• You have severe long-term heart, neurological, kidney, or blood-related disease.
• Your overall health and ability to carry out daily activities is significantly limited (confirm with trial site regarding the specific scoring scale used).
• You are unable to stay still in the required position for the duration of the treatment.
• You have a known allergy to a substance called Definity microbubbles (a contrast agent used in the procedure).
• You have significant heart problems, including a heart attack within the last six months, unstable chest pain, heart failure, irregular heart rhythms, a cardiac shunt, or a pacemaker.
• You have, or have a family history of, a heart rhythm condition called QT prolongation, or you are taking certain medications known to affect heart rhythm — such as some antibiotics, antidepressants, antipsychotics, or heart rhythm medications (confirm with trial site for the full medication list).
• A heart tracing (ECG) shows a prolonged QT interval beyond certain limits alongside heart problems (confirm with trial site for specific values).
• You have a history of bleeding disorders or problems with blood clotting.
• Your kidneys are severely impaired, or you are currently on dialysis.
• Your doctor has any other concern that they feel makes participation unsuitable for you.

Important: Always verify eligibility with the trial site directly before applying.