Phase 4 Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older and have been diagnosed with Parkinson's disease according to recognised medical guidelines (MDS 2015 criteria)
• You are experiencing psychotic symptoms (such as hallucinations or delusions) that require treatment with a medication called Clozapine
• Your blood test shows a normal white blood cell count and a normal level of a specific type of white blood cell called neutrophils before starting treatment
• You are able to have regular blood tests — weekly for the first 18 weeks of treatment, then at least every 4 weeks after that, and for 4 weeks after stopping Clozapine
• You are able to give your written agreement to take part in the trial after being fully informed about it
• You are covered by a social security (health insurance) system

Who may not be able to join:

• You have a medical reason that means you should not take Clozapine, as listed in the official medication guidelines
• You have a known allergy or sensitivity to Clozapine or any of its ingredients
• You are unable to have regular blood tests
• You have a history of a serious drop in certain white blood cells (granulopenia or agranulocytosis), unless this was caused by chemotherapy
• You have previously had a dangerous drop in white blood cells caused specifically by Clozapine
• You are currently taking certain other medications known to strongly increase the risk of dangerously low white blood cells, or long-acting injectable antipsychotic medications
• You have a condition where your bone marrow does not work properly
• You have epilepsy that is not well controlled
• Your psychotic symptoms are caused by alcohol, drugs, or poisoning, or you are in a coma
• You have severe problems with circulation or significant suppression of the central nervous system (confirm with trial site)
• You have serious kidney or heart problems (for example, inflammation of the heart called myocarditis)
• You have active liver disease with symptoms such as nausea, loss of appetite, or yellowing of the skin; or a worsening liver condition; or liver failure
• You have a condition called paralytic ileus, where the bowel stops working properly
• You have another condition or are taking treatments that weaken your immune system
• You are currently taking, or have taken in the last 5 years, medications that suppress or alter the immune system
• You are currently taking, or have taken in the last 5 years, anti-epileptic medications
• You have received chemotherapy in the last 5 years, or are currently receiving it
• You have been diagnosed with cancer (any type) in the last 5 years, or are still being treated for it
• You are living with HIV (Human Immunodeficiency Virus)
• You have a known inherited condition that affects your immune system
• You have a kidney condition called nephrotic syndrome
• You have a condition where your gut loses large amounts of protein (protein-losing enteropathy)
• You have a history of radiotherapy (radiation treatment)
• You have been taking steroid medications (such as corticosteroids) for a long period of time
• You scored 23 or below on a standard memory and thinking test called the MoCA, suggesting significant difficulties with thinking or memory
• You are pregnant or breastfeeding
• You are under legal guardianship or supervision, or you are not free to make your own decisions

Important: Always verify eligibility with the trial site directly before applying.