Phase 3 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You have been diagnosed with esophageal squamous cell cancer (a type of throat/food pipe cancer) that cannot be removed by surgery and has either spread to nearby areas or to other parts of the body, confirmed by a tissue or cell sample
• Your cancer got worse after receiving one previous treatment that included platinum-based chemotherapy and an immunotherapy drug (no more than one prior treatment course)
• You are able to provide a tissue sample from your tumor that meets the quality standards required by the trial
• You have at least one area of cancer that can be measured on a CT or MRI scan (not from a previously treated area, unless that is the only option and clear growth can be shown)
• Your general health and ability to carry out daily activities is rated as fully active or restricted only in physically strenuous activity (confirmed by a doctor within 7 days before starting treatment)

Who may not be able to join:

• You have previously received certain specific drugs targeting a protein called B7-H3, including orlotamab, enoblituzumab, or similar treatments
• You have previously received a type of chemotherapy called a topoisomerase inhibitor
• Your cancer has been confirmed as a specific subtype called adenosquamous carcinoma
• You are unable to tolerate any of the chemotherapy options used in the comparison group of this trial due to previous reactions or disease progression
• Your cancer is growing into nearby critical structures such as the aorta (main blood vessel) or airways, putting you at higher risk of bleeding or abnormal connections forming between organs (confirm with trial site)
• You have active or symptomatic brain metastases (cancer that has spread to the brain), spinal cord compression, or cancer affecting the lining of the brain or spinal cord that is untreated or needs medication to control symptoms — though stable, treated brain metastases with no symptoms and no steroid use for at least 2 weeks may be acceptable (confirm with trial site)
• You have had a stroke, mini-stroke, other arterial blood clot event, or a blood clot in the lungs within the past 6 months
• You have a significant disease affecting the surface of your eyes (corneal disease)
• You have a history of non-infectious lung inflammation (ILD/pneumonitis) that needed steroid treatment, or you currently have or are suspected to have this condition
• You have serious lung problems from any cause, including severe asthma, COPD, restricted lung function, fluid around the lungs, a previous lung removal surgery, or a need for supplemental oxygen
• You are currently taking regular steroid medication at a dose of 10 mg or more of prednisone (or equivalent) per day — low-dose inhaled, topical skin, or joint-injection steroids may be acceptable (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.