Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Imaging (MRA or CTA scan) has confirmed a blockage in specific brain arteries (the ICA or MCA-M1), including blockages in the neck or brain area, and possibly with an additional related blockage.
• CTA imaging shows moderate to good blood flow around the blocked area (collateral flow).
• The person is 18 years of age or older.
• The person has a stroke severity score (NIHSS) of 2 or higher at the start, and this score is still 2 or higher just before being enrolled in the trial.
• Treatment through a blood vessel in the groin can be started between 24 and 72 hours after the stroke began, where "stroke onset" means the last time the person was known to be neurologically normal (people who had a stroke during sleep may also be eligible if they meet this time window).
• The person had little to no disability before the stroke, shown by a pre-stroke functioning score of 0–2 on a standard scale (modified Rankin Scale).
• The person is able and willing to return for all required follow-up visits as set out in the study plan.
• The person, or their legally authorised representative, has signed the informed consent form.

Who may not be able to join:

• The person has a serious, advanced, or terminal illness, or is not expected to live more than six months (as determined by the investigator).
• The person has a pre-existing medical, neurological, or psychiatric condition that would interfere with stroke assessments, or is already taking part in another drug or device study.
• The person is pregnant.
• The person has medical reasons preventing them from having both an MRI and a CT contrast scan (confirm with trial site for local criteria).
• The person has a known allergy to iodine and has previously not responded to medications given to prevent allergic reactions.
• The person was treated with a clot-dissolving drug (tPA) more than 4.5 hours after they were last known to be neurologically normal.
• The person has a known bleeding disorder, clotting factor deficiency, or is on blood-thinning medication with a clotting measure (INR) above 3.
• The person has signs of stroke in more than one area of the brain at the same time.
• The person had seizures at the time the stroke started, which raises doubt about the stroke diagnosis and makes it difficult to get an accurate baseline stroke severity score.
• The person's blood sugar level at the start is below 50 mg/dL (2.78 mmol/L) or above 400 mg/dL (22.20 mmol/L).
• The person's platelet count (cells that help blood clot) is below 50,000/µL.
• The person has severely high blood pressure that cannot be brought down with medication (above 185/110 mmHg).
• The person is currently taking part in another investigational drug, device study, or registry.
• The person is suspected to have a stroke caused by an infected clot, bacterial heart infection (endocarditis), or inflammation of brain blood vessels (vasculitis).
• The person has already had a mechanical clot removal procedure attempted within 24 hours of stroke onset.

Important: Always verify eligibility with the trial site directly before applying.