Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part and have signed a consent form agreeing to participate.
• People aged between 18 and 80 years old.
• People who have been confirmed through laboratory testing (from tissue or fluid samples) to have a specific type of prostate cancer called adenocarcinoma, with no more than 10% neuroendocrine components, and without certain rare cancer cell types (small cell or signet ring cell features).
• People who have been newly diagnosed with prostate cancer that has spread to other parts of the body — such as lymph nodes, bones, or organs — confirmed by medical imaging (such as PSMA/PET-CT, CT, or MRI).
• People who are not currently enrolled in, and do not plan to join, any other clinical trial.
• People with a good general level of physical functioning, assessed using a standard medical scale (ECOG score of 0 or 1, meaning fully active or able to carry out light activity) (confirm with trial site).
• People whose blood cell counts, liver function, kidney function, and blood clotting results fall within acceptable ranges as defined by the trial (confirm with trial site for specific values).

Who may not be able to join:

• People who have had a serious allergic reaction or intolerance to any of the medications used in this trial.
• People who have already been diagnosed with a form of advanced prostate cancer that no longer responds to hormone treatment (called mCRPC), have already had a specific prostate procedure (TURP), and do not currently have urinary blockage or blood in the urine.
• People with a limited spread of hormone-sensitive prostate cancer (called oligometastatic mHSPC) who are planning to have surgical removal of the prostate as their main treatment.
• People who have medical conditions that make a specific prostate procedure (TURP) unsafe for them, such as severe narrowing of the urethra or inability to pass a catheter.
• People who have a history of seizures, take medications that may increase the risk of seizures, or have had a stroke or mini-stroke within the past 12 months.
• People who have had major surgery within the 4 weeks before starting the trial treatment.
• People who have had a serious heart or blood vessel condition in the past 6 months, such as a heart attack, severe chest pain, significant heart failure, stroke, or a heart rhythm problem requiring medication.
• People with serious ongoing digestive problems, such as chronic diarrhoea or bowel blockage, that could affect how the body absorbs medication.
• People with active infections including HIV, hepatitis B, or hepatitis C that may affect treatment safety or effectiveness.
• People who have been diagnosed with another type of cancer in the past 3 years, except for a type of skin cancer (basal cell carcinoma) that has been fully treated and cured.
• People who have active cancer spread to the brain or the lining around the brain.
• People who are currently taking part in a trial using another experimental drug or medical device.
• People who are considered unlikely to follow the treatment plan or attend required follow-up appointments.
• People with any other condition the trial doctors believe could affect their safety or the reliability of the trial results — for example, uncontrolled high blood pressure, severe diabetes, or psychiatric conditions.

Important: Always verify eligibility with the trial site directly before applying.