Phase 2 Cervical Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Criteria that apply to both groups:

• People who are female and over 45 years old
• People who have been treated with a cone biopsy (a surgical procedure to remove abnormal tissue from the cervix) for a high-grade abnormal cervical lesion
• People whose HPV test came back positive at a follow-up check around 6 months after surgery (between 6 and 12 months is accepted), leading to a recommendation for a follow-up colposcopy with or without biopsy
• People who had abnormalities found at their follow-up colposcopy or a positive biopsy result are still eligible, whether or not they have been vaccinated

Additional criteria for the vaccinated group (clinical trial):

• People who have no medical reason preventing them from receiving the Gardasil 9 HPV vaccine
• People who have agreed to receive the Gardasil 9 HPV vaccine
• People who are enrolled in the French social security system
• People who have given written informed consent to participate
• People living with HIV are eligible for the vaccinated group, provided they are currently on HIV treatment

Criteria for the non-vaccinated group (data study):

• People who meet the general criteria above but are not joining the vaccinated group, either because they declined vaccination or have a medical reason preventing vaccination
• People who do not object to their personal data being used for research purposes
• Note: Someone who initially declined vaccination may later choose to join the vaccinated group by signing a consent form, provided vaccination begins within 6 months of the initial positive HPV test

Who may not be able to join:

For both groups:

• People who have previously received a primary course of HPV vaccination
• People who have a history of an invasive cancer caused by HPV, including cervical, vaginal, vulvar, anal, or throat cancer

For the vaccinated group only:

• People who decline HPV vaccination
• People who have a medical reason that prevents them from receiving the Gardasil 9 vaccine
• People who are currently detained or under legal guardianship

For the non-vaccinated group only:

• People who object to their personal data being used for research purposes

Important: Always verify eligibility with the trial site directly before applying.