Early Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part, have signed a consent form, and are able to follow the study requirements
• You are 18 years of age or older
• You have been diagnosed with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer, confirmed by a tissue or cell sample
• A tumor tissue sample is available for testing, and results show a specific protein called HER2 is present at certain levels (IHC 1+, 2+, or 3+)
• You are generally active and able to care for yourself (confirm with trial site)
• Your life expectancy is expected to be more than 12 weeks
• Your heart, bone marrow, liver, and kidneys are functioning well enough, based on blood tests
• You have at least one measurable area of cancer that can be tracked on scans
• If you could become pregnant, you must either have been surgically sterilised, have been through menopause for at least one year, or have a negative pregnancy test before starting and agree to use an approved method of contraception throughout the study, and must not be breastfeeding

Who may not be able to join:

• You have previously been treated with certain types of targeted cancer drugs called HER2 ADC drugs, or similar drugs like anlotinib hydrochloride
• Your cancer did not respond to platinum-based chemotherapy from the start
• You have untreated cancer that has spread to the brain or the lining of the brain, or a history of cancer in the membranes surrounding the brain
• You have symptoms of a bowel blockage and need fluids or nutrition given directly into a vein
• You have a history of significant bleeding, any bleeding event of grade 3 or above in the past 4 weeks, or you have wounds, fractures, active stomach ulcers, or certain digestive conditions that have not healed
• You have had a serious blood clot event in the past 6 months, such as a stroke, deep vein clot, or pulmonary embolism (note: people on preventative blood-thinning treatment may still be eligible — confirm with trial site)
• You have serious heart or blood vessel problems, including a history of heart failure, dangerous irregular heart rhythms, angina, recent heart attack, significant heart valve disease, or very poorly controlled high blood pressure
• Side effects from previous cancer treatments have not yet settled down to a mild or absent level (except for hair loss)
• You have had major surgery within the past 4 weeks and have not fully recovered, or you are expected to need surgery during the study
• You have had another type of cancer within the past 3 years (some exceptions apply for certain treated skin cancers and other fully treated cancers with no signs of return — confirm with trial site)
• Scans show the tumour has grown into, or is very likely to grow into, major blood vessels in a way that could cause serious bleeding
• You have fluid build-up in the chest, heart, or abdomen that requires repeated draining, or you have had it drained within the past month
• You have a known allergy to any of the ingredients in the study medication
• You are currently pregnant or breastfeeding
• You have other serious health conditions or any other reason the trial doctor feels makes the study unsuitable for you

Important: Always verify eligibility with the trial site directly before applying.