Phase 2 COPD Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have received a stem cell (bone marrow) transplant from a donor (not your own cells)
• You are aged 12 or older
• You have been diagnosed with chronic Graft-versus-Host Disease (cGVHD) — a condition where the donor cells attack your body — and need a new treatment after already trying at least 2 other treatments, or because steroids have stopped working, or because you cannot reduce your steroid dose without symptoms returning
• Any other cGVHD treatments (apart from steroids and any transplant-related preventive medications) have been stopped before joining the study
• You are reasonably active and able to care for yourself, based on a standard health scoring scale (scores 0–3 out of 4)
• Your blood platelet count and white blood cell count are above certain minimum levels at the time of screening
• Your liver enzyme levels are within an acceptable range (or are elevated only because of cGVHD)
• Your steroid dose has been stable for at least 14 days before starting treatment
• If you are sexually active and able to have children, you are willing to use contraception as required by the study

Who may not be able to join:

• You are pregnant or breastfeeding
• Your original cancer or condition that led to the transplant has come back (is actively relapsing)
• You have a history of, or currently have, lung inflammation (scarring or irritation of lung tissue caused by illness or medication)
• You are currently experiencing active bleeding in your stomach or intestines
• Your kidneys, liver, lungs, or heart are not strong enough to safely handle the treatment process — for example, if your heart pumping strength is below 40% (confirm with trial site)
• You have a history of muscle inflammation (myositis)
• You have had your spleen removed
• You have a history of pancreatitis (inflammation of the pancreas)
• You have had another cancer diagnosed within the last 3 years, unless it was fully treated with the aim of curing it and the lead doctor approves
• You have other serious or poorly controlled health conditions, or you are unable to follow the study requirements
• You have HIV/AIDS, or currently have an active hepatitis B or hepatitis C infection
• You have previously been treated with a specific type of drug that targets a protein called CSF-1R (confirm with trial site)
• You have previously tried the main treatment used in this study (called ECP) and it did not work or you could not tolerate it
• You are allergic or intolerant to certain medications used in the treatment process: methoxsalen, heparin, or citrate products
• You do not have a lens in one or both eyes (aphakia), or you have a condition that makes your skin very sensitive to light (such as lupus, albinism, or porphyria)
• You do not have reliable access to a vein or central line for regular intravenous (IV) treatment
• Your health insurance has refused to cover the cost of the ECP treatment procedure

Important: Always verify eligibility with the trial site directly before applying.